Klemfuss H, Kripke D F
Life Sci. 1987 Jun 29;40(26):2531-8. doi: 10.1016/0024-3205(87)90075-0.
We tested whether a high potassium diet alters lithium's effects on locomotor activity rhythms to the same extent as it prevents lithium toxicity. Rats fed a standard diet containing 0.47% potassium lost weight after subcutaneous implantation of an osmotic pump delivering 1.35 mg of lithium chloride per hour, and most died or became sick within three weeks after implantation. In contrast, all rats fed a diet containing 4.1% potassium gained weight at the same rate regardless of whether they had received lithium infusions or placebo. In a second experiment, lithium administration by either diet or osmotic pump delayed wheel running rhythms, showing that lithium's central nervous system action did not depend on potassium intake or method of lithium administration. Dietary potassium supplementation may provide a useful strategy for improving the therapeutic index of lithium treatment.
我们测试了高钾饮食是否会像预防锂中毒一样，在相同程度上改变锂对运动活动节律的影响。喂食含0.47%钾的标准饮食的大鼠，在皮下植入每小时输送1.35毫克氯化锂的渗透泵后体重减轻，并且大多数在植入后三周内死亡或生病。相比之下，所有喂食含4.1%钾饮食的大鼠，无论是否接受锂输注或安慰剂，体重均以相同速率增加。在第二个实验中，通过饮食或渗透泵给予锂都会延迟转轮节律，表明锂的中枢神经系统作用不依赖于钾的摄入或锂的给药方法。补充膳食钾可能为提高锂治疗的治疗指数提供一种有用的策略。
