Olesen O V, Thomsen K
Neuropsychobiology. 1976;2(2-3):112-7. doi: 10.1159/000117538.
The effect of potassium against lithium intoxication was studied in two groups of rats given food containing 100 mmol of sodium and 100 or 1,100 mmol of potassiam/kg dry weight. After 1 week 80 mmol of lithium chloride/kg dry weight was added to both diets. Four days later the body weight, serum lithium concentration, and urinary lithium clearance were all significantly higher in the high potassium group than in the other group. After 15 days the lithium clearance had fallen to one fifth in the lowest potassium group but was unaltered in the high potassium group. All rats in the low potassium group continued to lose weight and died of lithium intoxication within 20 days, while the rats given high potassium survived and gained weight. A high potassium content of the food was able to prevent a fatal lithium-induced loss of sodium and to maintain a normal lithium clearance. It is suggested that also a lithium-induced loss of potassium was counteracted.
在两组大鼠中研究了钾对锂中毒的影响。这两组大鼠食用的食物中每千克干重含有100毫摩尔钠以及100或1100毫摩尔钾。1周后，两种饮食中均添加每千克干重80毫摩尔氯化锂。4天后，高钾组的体重、血清锂浓度和尿锂清除率均显著高于另一组。15天后，低钾组的锂清除率降至五分之一，而高钾组则未改变。低钾组的所有大鼠继续体重减轻，并在20天内死于锂中毒，而给予高钾的大鼠存活并体重增加。食物中的高钾含量能够防止锂诱导的致命性钠流失，并维持正常的锂清除率。提示锂诱导的钾流失也得到了抵消。
