Hughes R N
Life Sci. 1987 Jul 6;41(1):25-9. doi: 10.1016/0024-3205(87)90552-2.
Rearing, ambulation and occupancy of the novel half of an exploration box were observed in Wistar albino rats following intraperitoneal injections of saline, 0.03 or 0.06 mg/kg adrenalin. All three responses were decreased by the drug in a dose-related manner. Adrenalin did not seem to impair ability to discriminate between novel and familiar stimuli since the percentage of rearing that occurred in the novel half was highest in rats who received the 0.06 mg/kg dose. It was concluded that the suppression of novelty choices (and probably rearing and ambulation) by adrenalin was mainly due to its aversive peripheral properties. Pretreatment with 20 mg/kg oxprenolol HCl largely prevented the effects observed earlier, thereby implicating -adrenoceptors in adrenalin's behavioral action.
在向Wistar白化大鼠腹腔注射生理盐水、0.03或0.06mg/kg肾上腺素后，观察它们在探索箱新的一半区域的饲养、走动和停留情况。药物以剂量相关的方式降低了所有这三种反应。肾上腺素似乎并未损害大鼠区分新刺激和熟悉刺激的能力，因为在接受0.06mg/kg剂量的大鼠中，在新的一半区域发生的饲养百分比最高。得出的结论是，肾上腺素对新奇选择（可能还有饲养和走动）的抑制主要归因于其外周厌恶特性。用20mg/kg盐酸氧烯洛尔预处理在很大程度上阻止了早期观察到的效应，从而表明β-肾上腺素受体参与了肾上腺素的行为作用。
