Hughes R N
Department of Psychology, University of Canterbury, Christchurch, New Zealand.
Pharmacol Biochem Behav. 1992 Sep;43(1):125-9. doi: 10.1016/0091-3057(92)90648-y.
Novelty-related location preferences and activity in an exploration box were recorded for male and female Wistar albino rats following intraperitoneal injections of 0.04 or 0.08 mg/kg of either physostigmine or neostigmine. Although rearing was reduced by the highest dose of both drugs and ambulation was reduced by the same dose of neostigmine, neither agent affected the significant preferences for novelty that typified all subjects. In a second experiment designed to assess the effects of 0.08 mg/kg of the two drugs administered during rather than after confinement to the familiar half of the apparatus, neostigmine reduced rearing, walking, and ambulation while increasing defecation, but physostigmine did not affect any response. While some minor motor impairment may have arisen from its peripheral effects, the lack of changes in novelty-related location preferences failed to support facilitation of either novelty avoidance or habituation by physostigmine suggested in previous studies.
在雄性和雌性Wistar白化大鼠腹腔注射0.04或0.08mg/kg的毒扁豆碱或新斯的明后，记录它们在探索箱中与新奇相关的位置偏好和活动情况。虽然两种药物的最高剂量均降低了大鼠的竖毛行为，相同剂量的新斯的明降低了大鼠的移动行为，但两种药物均未影响所有实验对象对新奇事物的显著偏好。在第二个实验中，为了评估在大鼠被限制在熟悉的装置一半区域期间而非之后给予0.08mg/kg这两种药物的效果，结果发现新斯的明减少了大鼠的竖毛、行走和移动行为，同时增加了排便，但毒扁豆碱对任何反应均无影响。虽然其外周效应可能导致了一些轻微的运动障碍，但与新奇相关的位置偏好没有变化，这并不支持先前研究中所提出的毒扁豆碱促进新奇回避或习惯化的观点。
