控制女王的生殖能力：掌握生殖药物的使用以调控周期性。
Reversible Control of Reproduction In Queens: Mastering the use of reproductive drugs to manipulate cyclicity.
机构信息
Department of Animal Medicine, Production and Health, University of Padova, Italy.
San Marco Veterinary Clinic and Laboratory, Padova, Italy.
出版信息
J Feline Med Surg. 2022 Sep;24(9):853-870. doi: 10.1177/1098612X221118754.
BACKGROUND
The literature is full of papers reporting side effects of progestogens in cats; however, they are, in fact, safe drugs, as discussed in this article. Gonadotropin-releasing hormone (GnRH) agonists and melatonin are additionally a practical solution for controlling cyclicity in queens, but they also have some contraindications and need to be used carefully.
CLINICAL RELEVANCE
Mastering the use of reproductive drugs allows feline practitioners to handle many more clinical situations than can be solved using surgery. It is not necessary to be a specialist in reproduction to be able to halt cyclicity in a valuable breeding queen using hormones.
EQUIPMENT AND TECHNICAL SKILLS
A sound knowledge of appropriate dosages and criteria for patient selection for all reproductive drugs currently used in feline reproduction is the best guarantee of owner satisfaction and of ensuring the queen's health. Availability of a serum progesterone assay, either in-house or via an external laboratory, is also important, in order to confirm a queen is at an appropriate stage of the reproductive cycle for treatment.
AUDIENCE
This article is aimed principally (but not exclusively) at veterinarians working with cat breeders and whose clientele is increasingly interested in alternative methods of controlling reproduction in pet queens. Surgery is no longer the only choice, and practitioners who manage to keep abreast of new developments will be able to address clients' needs in a modern, professional way.
EVIDENCE BASE
This review draws on a vast body of scientific evidence-based literature. Previously, personal (and sometimes misinformed) opinions, such as the proposed dangerous side effects of progestogens, have been perpetuated in the scientific literature. The papers cited in this review have therefore been carefully scrutinised to distinguish reliable information based on controlled studies from non-evidence-based information.
背景
文献中充斥着大量关于孕激素在猫中副作用的报道；然而，正如本文所讨论的，它们实际上是安全的药物。促性腺激素释放激素（GnRH）激动剂和褪黑素也是控制母猫周期性的实用解决方案，但它们也有一些禁忌症，需要谨慎使用。
临床相关性
掌握生殖药物的使用可以让猫科医生处理更多的临床情况，而不仅仅是通过手术来解决。即使不是繁殖方面的专家，也可以使用激素来停止有价值的繁殖母猫的周期性。
设备和技术技能
熟悉目前在猫科动物繁殖中使用的所有生殖药物的适当剂量和患者选择标准，是保证主人满意度和确保母猫健康的最佳保证。拥有血清孕激素检测，无论是内部还是外部实验室提供的，对于确认母猫处于适当的生殖周期阶段以便进行治疗也很重要。
听众
本文主要（但不仅限于）针对与猫饲养者合作的兽医，并且他们的客户群体越来越感兴趣于控制宠物母猫繁殖的替代方法。手术不再是唯一的选择，那些能够跟上新发展的从业者将能够以现代、专业的方式满足客户的需求。
证据基础
这篇综述借鉴了大量基于科学证据的文献。以前，个人（有时是错误的）观点，如孕激素被提议的危险副作用，在科学文献中一直存在。因此，本文引用的论文都经过了仔细审查，以区分基于对照研究的可靠信息与无证据的信息。
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