Nascimento Acácia Eduarda de Jesus, Santos Luciano Cardoso, Silva Juneo Freitas
Centro de Microscopia Eletronica, Departamento de Ciencias Biologicas, Universidade Estadual de Santa Cruz, Campus Soane Nazare de Andrade, Ilheus 45662-900, Brazil.
Animals (Basel). 2024 Oct 16;14(20):2987. doi: 10.3390/ani14202987.
Pyometra is a major reproductive disorder affecting female cats. Characterized by the accumulation of purulent exudate in the uterus, it can lead to severe and potentially fatal complications. This pathology primarily occurs in adult cats during diestrus, but can also affect younger felines, often due to inappropriate administration of hormonal medications. While the etiopathogenesis of pyometra is better understood in bitches, few studies have addressed the molecular factors involved in feline pyometra. Therefore, this review aims to provide an up-to-date and comprehensive discussion of pyometra in cats, focusing on the regulation of molecular factors described in this species, including hormonal, redox, immunological, and growth factors. Understanding the regulation of these factors in pyometra is crucial for elucidating its pathogenesis in domestic cats and for improving diagnosis and identifying novel therapeutic approaches.
子宫蓄脓是影响母猫的一种主要生殖系统疾病。其特征是子宫内积聚脓性渗出物，可导致严重且可能致命的并发症。这种病症主要发生在成年母猫的间情期，但也可能影响较年轻的猫科动物，通常是由于激素药物使用不当所致。虽然犬子宫蓄脓的病因发病机制已得到较好的了解，但针对猫子宫蓄脓所涉及的分子因素的研究较少。因此，本综述旨在对猫子宫蓄脓进行最新且全面的讨论，重点关注该物种中所描述的分子因素的调节，包括激素、氧化还原、免疫和生长因子。了解这些因素在子宫蓄脓中的调节对于阐明其在家猫中的发病机制、改善诊断以及确定新的治疗方法至关重要。
