Department of Preventive Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Institute of Health Services Research, Yonsei University, Seoul, Republic of Korea.
J Headache Pain. 2022 Aug 24;23(1):108. doi: 10.1186/s10194-022-01484-y.
Studies investigating the association between migraine and dementia have reported inconsistent findings. This study aimed to evaluate whether patients with migraine have an increased risk of dementia compared to individuals without migraine.
We obtained data from the 2002-2019 Korean National Health Insurance Health Screening Cohort. Non-migraine controls were selected using a 1:1 risk-set matching with a time-dependent propensity score. The main outcome was the development of all-cause dementia, and the secondary outcome was the development of each cause of dementia (Alzheimer's, vascular, mixed or other specified, and unspecified dementia). The incidence rate of dementia was calculated using Poisson regression, and the association between migraine and dementia was evaluated using Cox proportional hazards regression.
Among 88,390 participants, 66.1% were female, and the mean baseline age was 55.3 ± 9.4 years. During the study period, dementia cases were identified in 4,800 of the 44,195 patients with migraine and 3,757 of the 44,915 matched controls. The incidence rate of dementia was 139.6 (95% confidence interval [CI], 135.7-143.5) and 107.7 (95% CI, 104.3-111.1) cases per 10,000 person-years in patients with migraine and matched controls, respectively. Patients with migraine had a 1.30 (hazard ratio [HR], 1.30; 95% CI, 1.25-1.35), 1.29 (HR, 1.29; 95% CI, 1.23-1.35), 1.35 (HR, 1.35; 95% CI, 1.19-1.54), 1.36 (HR, 1.36; 95% CI, 1.00-1.83), and 1.30 (HR, 1.30; 95% CI, 1.17-1.45) times higher risk of developing all-cause dementia, Alzheimer's dementia, vascular dementia, mixed or other specified dementias, and unspecified dementia than their matched controls, respectively.
Our results suggest that migraine is associated with an increased risk of subsequent dementia. Further research is warranted to confirm these findings and to reveal the underlying mechanisms.
研究偏头痛与痴呆之间的关联的报告结果并不一致。本研究旨在评估偏头痛患者与非偏头痛患者相比，是否有更高的痴呆风险。
我们从 2002 年至 2019 年韩国国家健康保险健康筛查队列中获取数据。使用基于时间的倾向评分的 1:1 风险集匹配选择非偏头痛对照。主要结局是全因痴呆的发生，次要结局是每种原因的痴呆（阿尔茨海默病、血管性、混合或其他特定性和未特定性痴呆）的发生。使用泊松回归计算痴呆的发生率，使用 Cox 比例风险回归评估偏头痛与痴呆之间的关系。
在 88390 名参与者中，66.1%为女性，平均基线年龄为 55.3±9.4 岁。在研究期间，4800 名偏头痛患者和 44915 名匹配对照者中确诊为痴呆病例。偏头痛患者和匹配对照者的痴呆发生率分别为 139.6（95%置信区间[CI]，135.7-143.5）和 107.7（95% CI，104.3-111.1）例/10000 人年。偏头痛患者发生全因痴呆的风险比（HR）为 1.30（95% CI，1.25-1.35）、1.29（HR，1.29；95% CI，1.23-1.35）、1.35（HR，1.35；95% CI，1.19-1.54）、1.36（HR，1.36；95% CI，1.00-1.83）和 1.30（HR，1.30；95% CI，1.17-1.45）倍，与匹配对照者相比，患所有原因痴呆、阿尔茨海默病痴呆、血管性痴呆、混合或其他特定性痴呆以及未特定性痴呆的风险更高。
我们的研究结果表明，偏头痛与随后发生痴呆的风险增加有关。需要进一步的研究来证实这些发现并揭示潜在的机制。
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