Division of Epidemiology, Department of Public Health Sciences, University of California Davis Medical Center, Davis, CA, USA.
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Headache. 2020 May;60(5):946-953. doi: 10.1111/head.13794. Epub 2020 Mar 22.
We aimed to assess the association between migraine headache and incident dementia.
Migraine is a risk factor for white matter hyperintensities and ischemic stroke, which are both associated with increased risk of dementia. However, it is unknown whether migraine is independently associated with dementia.
History of migraine was ascertained via questionnaire. Adjudicated cases of dementia were identified using cognitive tests, neuropsychological exams, and clinician review of suspected cases. Incident dementia was identified using adjudicated cases, follow-up calls, and surveillance of hospital and death codes. We assessed hazards of incident dementia by migraine status. Sex differences were also examined and stratified results were presented.
Analysis included 12,495 White and African American participants ages 51-70 with a median follow-up time of 21 years. Prevalence of dementia was 18.5% (1821/9955) among those with no migraine history, 15.8% (196/1243) among those with severe non-migraine heading, and 16.7% (233/1397) among migraineurs. There was no association between migraine and incident dementia [hazard ratio: 1.04 (0.91, 1.20)]. There was also no statistically significant interaction between sex and migraine status on risk of dementia.
Despite evidence of brain abnormalities in migraineurs, there was no association between migraine and incident dementia in this prospective cohort.
评估偏头痛与痴呆症发病之间的关联。
偏头痛是脑白质高信号和缺血性中风的危险因素，而这两种疾病都与痴呆症风险增加有关。然而，目前尚不清楚偏头痛是否与痴呆症有独立关联。
通过问卷调查确定偏头痛病史。通过认知测试、神经心理学检查和疑似病例的临床医生审查来确定痴呆症的确诊病例。通过确诊病例、随访电话和医院及死亡代码的监测来确定痴呆症的发病情况。我们通过偏头痛状况评估痴呆症发病的风险。还检查了性别差异，并呈现了分层结果。
分析包括 12495 名年龄在 51-70 岁的白人和非裔美国人参与者，中位随访时间为 21 年。无偏头痛史者痴呆症患病率为 18.5%（1821/9955），重度非偏头痛者为 15.8%（196/1243），偏头痛患者为 16.7%（233/1397）。偏头痛与痴呆症发病之间无关联[风险比：1.04（0.91，1.20）]。性别和偏头痛状况对痴呆症风险之间也没有统计学上显著的交互作用。
尽管偏头痛患者存在脑部异常的证据，但在这项前瞻性队列研究中，偏头痛与痴呆症发病之间没有关联。
