College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
J Cardiothorac Surg. 2022 Aug 24;17(1):204. doi: 10.1186/s13019-022-01965-w.
Bronchial anastomotic dehiscence is considered one of the most catastrophic early airway complications post-transplant. The presence of a partial dehiscence can also cause further complications such as a fistula between the bronchus and the pleural membrane. Platelet-rich plasma (PRP) is known to significantly enhance the healing process and is being used in the treatment of various conditions, however, so far, there are no reports of the use of PRP in the treatment of bronchial anastomotic dehiscence fistula.
We present a 37-year-old male, with non-cystic fibrosis bronchiectasis underwent bilateral lung transplantation. The patient developed partial dehiscence of the right bronchial anastomosis that was complicated by a small bronchopleural fistula. Two bronchoscopic applications of autologous platelet-rich plasma were carried out. Follow-up a few weeks later showed complete closure and healing of the fistula.
This case report suggests that the treatment of post-lung transplant small bronchial anastomotic partial dehiscence fistula with PRP is safe and effective.
支气管吻合口裂开被认为是移植后最严重的早期气道并发症之一。部分裂开的存在也可能导致进一步的并发症，如支气管与胸膜膜之间的瘘管。富血小板血浆（PRP）已被证实能显著促进愈合过程，并被用于治疗各种疾病，但迄今为止，尚无 PRP 用于治疗支气管吻合口裂开瘘的报道。
我们报告了一例 37 岁男性，患有非囊性纤维化性支气管扩张症，行双侧肺移植。患者发生了右支气管吻合口部分裂开，并伴有小的支气管胸膜瘘。进行了两次支气管镜下应用自体富血小板血浆的治疗。几周后的随访显示瘘管完全闭合和愈合。
本病例报告提示，PRP 治疗肺移植后小的支气管吻合口部分裂开瘘是安全有效的。
