R&D Center LaborQ, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018 Bucharest, Romania.
Department of Analytical Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018 Bucharest, Romania.
Biosensors (Basel). 2022 Aug 6;12(8):608. doi: 10.3390/bios12080608.
Roadside testing of illicit drugs such as tetrahydrocannabinol (THC) requires simple, rapid, and cost-effective methods. The need for non-invasive detection tools has led to the development of selective and sensitive platforms, able to detect phyto- and synthetic cannabinoids by means of their main metabolites in breath, saliva, and urine samples. One may estimate the time passed from drug exposure and the frequency of use by corroborating the detection results with pharmacokinetic data. In this review, we report on the current detection methods of cannabinoids in biofluids. Fluorescent, electrochemical, colorimetric, and magnetoresistive biosensors will be briefly overviewed, putting emphasis on the affinity formats amenable to on-site screening, with possible applications in roadside testing and anti-doping control.
roadside 检测非法药物，如四氢大麻酚（THC），需要简单、快速和具有成本效益的方法。非侵入性检测工具的需求导致了选择性和敏感性平台的发展，这些平台能够通过呼吸、唾液和尿液样本中的主要代谢物来检测植物源和合成大麻素。通过将检测结果与药代动力学数据相印证，可以估计从药物暴露到使用频率的时间。在这篇综述中，我们报告了生物流体中大麻素的当前检测方法。简要概述了荧光、电化学、比色和磁阻生物传感器，重点介绍了适用于现场筛选的亲和格式，这些格式可能应用于路边检测和反兴奋剂控制。
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