Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Center for Integrated Oncology (CIO) Aachen-Bonn-Cologne-Duesseldorf, Cologne, Germany.
Neurosignals. 2022 Aug 25;30(S1):21-38. doi: 10.33594/000000560.
Malignant tumors of the eyelids and ocular surface are common ocular malignancies. At present, surgical treatment is mostly the first choice for these types of tumors. However, postoperative tumor recurrence and metastasis are still regarded as failures in the treatment of such malignancies. Based on this, malignant tumors of the eyelid and ocular surface are sometimes accompanied by local adjuvant chemotherapy and systemic chemotherapy to treat patients with relapse, invasion of adjacent tissues, and systemic metastases. Still, drug resistance greatly affects the treatment effect. This review lists several mechanisms of recurrence and metastasis of ocular surface and eyelid tumors after surgery, as well as mechanisms that may lead to non-surgical treatment or drug resistance.
眼睑和眼表面的恶性肿瘤是常见的眼部恶性肿瘤。目前，手术治疗仍是治疗此类肿瘤的首选方法。然而，术后肿瘤复发和转移仍被视为此类恶性肿瘤治疗的失败。基于此，有时会对眼睑和眼表面的恶性肿瘤进行局部辅助化疗和全身化疗，以治疗复发、侵犯邻近组织和全身转移的患者。然而，药物耐药性极大地影响了治疗效果。这篇综述列出了手术后眼表面和眼睑肿瘤复发和转移的几种机制，以及可能导致非手术治疗或耐药性的机制。
