Buján Bonino Cecilia, Rodríguez-Blanco Isabel, Sánchez-Aguilar Rojas Dolores, Vázquez Veiga Hugo A, Flórez Ángeles
Department of Dermatology, University Hospital of Santiago de Compostela, 36001 Santiago de Compostela, Spain.
Department of Dermatology, University Hospital of Pontevedra, 36162 Pontevedra, Spain.
Cancers (Basel). 2023 Oct 17;15(20):5018. doi: 10.3390/cancers15205018.
The use of topical and intralesional immunotherapy in the treatment of cutaneous malignant neoplasia in sensitive areas such as the lips and eyelids is discussed. Surgery may not be feasible or may result in deformities in these areas, making alternative treatment options necessary. A narrative literature review was conducted using MEDLINE (PubMed) as the main literature database, collecting available evidence of experiences with various topical and intralesional therapies in the aforementioned anatomical locations, ranging from case reports to clinical trials. The clearance rates and potential adverse reactions of therapeutic options such as imiquimod 5%, 5-fluorouracil (5-FU), photodynamic therapy (PDT), ingenol mebutate (IM), diclofenac, intralesional methotrexate, and interferon are reviewed. Although limited by their heterogeneity and the scarcity of clinical trials, these studies point towards promising response rates and minimal adverse effects, making these treatments viable options in selected cases.
本文讨论了局部和病灶内免疫疗法在治疗唇部和眼睑等敏感部位皮肤恶性肿瘤中的应用。手术在这些部位可能不可行或可能导致畸形，因此需要其他治疗选择。以MEDLINE（PubMed）作为主要文献数据库进行了叙述性文献综述，收集了在上述解剖部位使用各种局部和病灶内疗法的经验证据，范围从病例报告到临床试验。综述了咪喹莫特5%、5-氟尿嘧啶（5-FU）、光动力疗法（PDT）、鬼臼毒素软膏（IM）、双氯芬酸、病灶内甲氨蝶呤和干扰素等治疗选择的清除率和潜在不良反应。尽管这些研究受到其异质性和临床试验稀缺性的限制，但它们显示出有前景的缓解率和最小的不良反应，使这些治疗在特定病例中成为可行的选择。
