U.O.C. Oncologia Oculare, Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa Collo, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Department of Ophthalmology, University of Lübeck, University Hospital Schleswig-Holstein, Lübeck, Germany.
Neurosignals. 2022 Mar 25;30(S1):1-10. doi: 10.33594/000000505.
The goal of radiotherapy in the treatment of eyelid and ocular surface tumors is to eradicate tumor burden in a manner that maintains visual function and preserve surrounding sensitive ocular tissue. Interventional radiotherapy (IRT-brachytherapy) is a radiotherapy technique associated with a highly focal dose distribution, with the advantage of boosting limited size target volumes to very high dose while sparing normal tissue. The reduction in the ocular and adnexal complications that result from this form of therapy, has led in recent years, to an increase in the use of IRT for the treatment of eyelid and ocular surface tumors. For eyelid malignancies, IRT is used as an independent treatment in small eyelids tumors, in postoperative treatment of high-risk patients and as well as salvage therapy in local recurrences. In the treatment of conjunctival malignancies, due to the high risk of local recurrence, the use of adjuvant therapies as IRT has shown to improve outcomes. In this review, we focus on eyelid and ocular surface IRT techniques and provide an overview of indication, outcomes and toxicity of IRT for the treatment of naïve and recurrent eyelid and conjunctival tumors.
放疗在眼睑和眼表面肿瘤治疗中的目标是以保持视觉功能和保护周围敏感眼组织的方式消除肿瘤负担。介入放疗（IRT-近距离放疗）是一种放疗技术，具有非常高的焦点剂量分布优势，能够将有限大小的靶体积提升至非常高的剂量，同时保护正常组织。这种治疗方式减少了眼部和附属器并发症，近年来，IRT 在眼睑和眼表面肿瘤治疗中的应用有所增加。对于眼睑恶性肿瘤，IRT 可作为小眼睑肿瘤的独立治疗方法，用于高危患者的术后治疗以及局部复发的挽救治疗。在结膜恶性肿瘤的治疗中，由于局部复发的风险很高，作为辅助治疗的 IRT 已被证明可以改善预后。在这篇综述中，我们重点介绍了眼睑和眼表面 IRT 技术，并概述了 IRT 治疗初发性和复发性眼睑和结膜肿瘤的适应证、结果和毒性。
