Liu Chengzhi, Dong Wenkang, Li Jun, Kong Ying, Ren Xiang
The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Department of Histology and Embryology, College of Basic Medicine, Dalian Medical University, Dalian 116044, China.
Metabolites. 2022 Aug 5;12(8):725. doi: 10.3390/metabo12080725.
Diabetic retinopathy (DR) is a leading complication in type 1 and type 2 diabetes and has emerged as a significant health problem. Currently, there are no effective therapeutic strategies owing to its inconspicuous early lesions and complex pathological mechanisms. Therefore, the mechanism of molecular pathogenesis requires further elucidation to identify potential targets that can aid in the prevention of DR. As a type of protein translational modification, -linked β-N-acetylglucosamine (-GlcNAc) modification is involved in many diseases, and increasing evidence suggests that dysregulated -GlcNAc modification is associated with DR. The present review discusses -GlcNAc modification and its molecular mechanisms involved in DR. -GlcNAc modification might represent a novel alternative therapeutic target for DR in the future.
糖尿病视网膜病变（DR）是1型和2型糖尿病的主要并发症，已成为一个重大的健康问题。目前，由于其早期病变不明显且病理机制复杂，尚无有效的治疗策略。因此，需要进一步阐明分子发病机制，以确定有助于预防DR的潜在靶点。作为一种蛋白质翻译后修饰，O-连接的β-N-乙酰葡糖胺（O-GlcNAc）修饰参与多种疾病，越来越多的证据表明O-GlcNAc修饰失调与DR有关。本综述讨论了O-GlcNAc修饰及其在DR中的分子机制。O-GlcNAc修饰可能成为未来DR的一种新的替代治疗靶点。
