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述评:基因组学将彻底改变基因-环境相互作用的研究吗?

Commentary: Will genomics revolutionise research on gene-environment interplay?

机构信息

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Division of Psychology and Language Sciences, University College London, London, UK.

出版信息

J Child Psychol Psychiatry. 2022 Oct;63(10):1214-1218. doi: 10.1111/jcpp.13687. Epub 2022 Aug 25.

DOI:10.1111/jcpp.13687
PMID:36005740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9804537/
Abstract

The synthesis of quantitative genetics and molecular genetics is transforming research in the behavioural sciences. The ability to measure inherited DNA differences directly has led to polygenic scores and to new methods to estimate heritability and genetic correlations. This issue provides examples of how these advances can be appllied to research on gene-environment interplay in developmental psychopathology.

摘要

数量遗传学和分子遗传学的综合正在改变行为科学的研究。直接测量遗传 DNA 差异的能力导致了多基因评分以及新的方法来估计遗传力和遗传相关性。本期特刊提供了这些进展如何应用于发展心理病理学中基因-环境相互作用研究的例子。

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本文引用的文献

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Integrative analysis of genomic and exposomic influences on youth mental health.整合基因组和外显子组对青少年心理健康影响的分析。
J Child Psychol Psychiatry. 2022 Oct;63(10):1196-1205. doi: 10.1111/jcpp.13664. Epub 2022 Aug 10.
2
Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study.母亲和儿童的 ADHD 遗传风险、家庭混乱与儿童 ADHD 症状:基因-环境相关研究。
J Child Psychol Psychiatry. 2022 Oct;63(10):1153-1163. doi: 10.1111/jcpp.13659. Epub 2022 Jul 14.
3
How interactions between ADHD and schools affect educational achievement: a family-based genetically sensitive study.ADHD 与学校的相互作用如何影响教育成就:一项基于家庭的遗传敏感研究。
J Child Psychol Psychiatry. 2022 Oct;63(10):1174-1185. doi: 10.1111/jcpp.13656. Epub 2022 Jul 4.
4
Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation.精神分裂症和重度抑郁症的多基因评分与儿童的社会心理风险因素相关:基因-环境相关性的证据。
J Child Psychol Psychiatry. 2022 Oct;63(10):1140-1152. doi: 10.1111/jcpp.13657. Epub 2022 Jul 4.
5
On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families.论养育方式在外显障碍中的重要性:家庭中间接遗传效应的评估。
J Child Psychol Psychiatry. 2022 Oct;63(10):1186-1195. doi: 10.1111/jcpp.13654. Epub 2022 Jul 2.
6
Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year.青少年期自杀意念:自杀未遂的总体遗传易感性和过去一年中消极生活事件的作用。
J Child Psychol Psychiatry. 2022 Oct;63(10):1164-1173. doi: 10.1111/jcpp.13653. Epub 2022 Jun 29.
7
Gene-environment interplay in externalizing behavior from childhood through adulthood.从儿童期到成年期,外显行为的基因-环境相互作用。
J Child Psychol Psychiatry. 2022 Oct;63(10):1206-1213. doi: 10.1111/jcpp.13652. Epub 2022 Jun 29.
8
Research Review: A guide to computing and implementing polygenic scores in developmental research.研究综述:发展研究中计算和实施多基因评分的指南。
J Child Psychol Psychiatry. 2022 Oct;63(10):1111-1124. doi: 10.1111/jcpp.13611. Epub 2022 Mar 30.
9
Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes.研究综述:如何解释多基因评分、环境风险和表型之间的关联。
J Child Psychol Psychiatry. 2022 Oct;63(10):1125-1139. doi: 10.1111/jcpp.13607. Epub 2022 Mar 28.
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Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data.评估全基因组序列数据中稀有变异对复杂性状遗传度的贡献。
Nat Genet. 2022 Mar;54(3):263-273. doi: 10.1038/s41588-021-00997-7. Epub 2022 Mar 7.