Fonte Luis, Acosta Armando, Sarmiento María E, Norazmi Mohd Nor, Ginori María, de Armas Yaxsier, Calderón Enrique J
Department of Parasitology, Institute of Tropical Medicine "Pedro Kourí", Havana 11400, Cuba.
School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.
Trop Med Infect Dis. 2022 Jul 30;7(8):157. doi: 10.3390/tropicalmed7080157.
There is an increasing attention to the emerging health problem represented by the clinical and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19 syndrome. Clinical, radiographic, and autopsy findings have shown that a high rate of fibrosis and restriction of lung function are present in patients who have recovered from COVID-19. Patients with active TB, or those who have recovered from it, have fibrotic scarred lungs and, consequently, some degree of impaired respiratory function. Helminth infections trigger predominantly type 2 immune responses and the release of regulatory and fibrogenic cytokines, such as TGF-β. Here, we analyze the possible consequences of the overlapping of pulmonary fibrosis secondary to COVID-19 and tuberculosis in the setting of sub-Saharan Africa, the region of the world with the highest prevalence of helminth infection.
人们越来越关注由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的临床和功能长期后果所代表的新出现的健康问题，即新冠后综合征。临床、影像学和尸检结果表明，从新冠肺炎中康复的患者中存在高比例的肺纤维化和肺功能受限。活动性结核病患者或已从结核病中康复的患者，肺部有纤维化瘢痕，因此呼吸功能有一定程度的受损。蠕虫感染主要引发2型免疫反应，并释放调节性和促纤维化细胞因子，如转化生长因子-β（TGF-β）。在此，我们分析了在撒哈拉以南非洲地区（世界上蠕虫感染患病率最高的地区），新冠肺炎继发的肺纤维化与结核病重叠可能产生的后果。
