Departments of Nuclear Medicine.
Hematology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
Nucl Med Commun. 2022 Oct 1;43(10):1077-1083. doi: 10.1097/MNM.0000000000001608. Epub 2022 Aug 26.
This study aims to evaluate the relationships of metabolic fluorodeoxyglucose PET/computed tomography (FDG PET/CT) parameters such as whole-body metabolic tumor volume (WB MTV), WB-total lesion glycolysis (TLG), and bone marrow (BM)-mean standard uptake value (SUVmean) with clinical stage and other prognostic biomarkers in newly diagnosed multiple myeloma (MM) patients.
Patients who underwent pretreatment PET/CT with the diagnosis of MM were evaluated retrospectively. The number of focal lesions, WB MTV, WB TLG, and BM SUVmean values were measured on FDG PET/CT images. Clinical stages and prognostic laboratory parameters were recorded the pretreatment period.
WB MTV and WB TLG values were significantly higher in patients with more than three focal lesions on FDG PET/CT scan (all P < 0.001). According to the Revised International Staging System (R-ISS), all WB MTV, WB TLG, and BM SUVmean values are significantly higher in patients with stage 3 disease than in stages 1-2 ( P = 0.027, P = 0.019, P = 0.001, respectively). Serum creatinine level is positively correlated with WB MTV, WB TLG, and BM SUVmean values ( P = 0.020, P = 0.004, P < 0.001, respectively). In addition, the β2 microglobulin level, an essential biochemical prognostic parameter, was positively correlated with the BM SUVmean value ( P = 0.013).
The BM SUVmean, WB MTV, and WB TLG values, which reflect FDG avid WB tumor burden, are associated with prognostic biomarkers and R-ISS stage in newly diagnosed MM patients. It contributes to the identification of high-risk patients at the pretreatment staging.
本研究旨在评估代谢氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG PET/CT）参数，如全身代谢肿瘤体积（WB MTV）、全身总肿瘤糖酵解（WB TLG）和骨髓（BM）-平均标准摄取值（SUVmean）与新诊断多发性骨髓瘤（MM）患者的临床分期和其他预后生物标志物的关系。
回顾性评估了经诊断为 MM 并接受治疗前 PET/CT 的患者。在 FDG PET/CT 图像上测量了病灶数量、WB MTV、WB TLG 和 BM SUVmean 值。记录了治疗前的临床分期和预后实验室参数。
在 FDG PET/CT 扫描中存在多于 3 个病灶的患者中，WB MTV 和 WB TLG 值明显更高（均 P < 0.001）。根据修订后的国际分期系统（R-ISS），3 期患者的所有 WB MTV、WB TLG 和 BM SUVmean 值均明显高于 1-2 期（P = 0.027、P = 0.019、P = 0.001）。血清肌酐水平与 WB MTV、WB TLG 和 BM SUVmean 值呈正相关（P = 0.020、P = 0.004、P < 0.001）。此外，β2 微球蛋白水平，一种重要的生化预后参数，与 BM SUVmean 值呈正相关（P = 0.013）。
反映 FDG 摄取的全身肿瘤负荷的 BM SUVmean、WB MTV 和 WB TLG 值与新诊断 MM 患者的预后生物标志物和 R-ISS 分期相关。这有助于在治疗前分期时识别高危患者。
