Ayres K, Neuman W, Rowekamp W G, Chung S
Mol Cell Biol. 1987 May;7(5):1823-9. doi: 10.1128/mcb.7.5.1823-1829.1987.
We have studied two regions of Dictyostelium discoideum chromatin and identified several DNase I-hypersensitive sites in these regions. One of these sites is located about 300 to 500 bases upstream of the transcriptional start site of a gene that is expressed at all stages of development. This site is present in both vegetative cells and postaggregation cells. Another hypersensitive site is associated with a gene that is expressed only after the multicellular stage. This site is located about 400 bases upstream of the start site, and it is present only in postaggregation cells. Thus, much like higher eucaryotes, D. discoideum contains DNase I-hypersensitive sites that may be involved in the regulation of the genes with which they are associated.
我们研究了盘基网柄菌染色质的两个区域，并在这些区域鉴定出了几个脱氧核糖核酸酶I超敏位点。其中一个位点位于一个在发育的所有阶段都表达的基因转录起始位点上游约300至500个碱基处。该位点在营养细胞和聚集后细胞中均存在。另一个超敏位点与一个仅在多细胞阶段后才表达的基因相关。该位点位于起始位点上游约400个碱基处，且仅存在于聚集后细胞中。因此，与高等真核生物非常相似，盘基网柄菌含有可能参与与其相关基因调控的脱氧核糖核酸酶I超敏位点。
