College of Computer Science, Nankai University, No. 38 Tongyan Road, Tianjin 300071, China.
Centre for Bioinformatics and Intelligent Medicine, Nankai University, No. 38 Tongyan Road, Tianjin 300071, China.
Database (Oxford). 2022 Aug 25;2022. doi: 10.1093/database/baac073.
Although several traditional Chinese medicine (TCM)-related databases have emerged, they focus on researching single medicinal materials, which is far from sufficient for clinical research and application. In comparison, compound prescriptions are more informative and meaningful in TCM, for they embody the information on the compatibility of TCM besides the relatively isolated information about single medicinal materials. The compatibility information is essential in TCM because it conveys not only what components are involved to treat special diseases but also how to combine these single medical materials. We established a database of Chinese patent medicine and compound prescription (CPMCP). It demonstrates the prescription information of Chinese patent medicines (CPMs) and ancient Chinese medicine prescriptions (CMPs). CPMCP reports their comprehensive and standardized information such as the components, indications and contraindications. It is worth mentioning that we organized relevant experts and spent lots of time manually mapping the functions of compound prescriptions in ancient Chinese to the standardized TCM symptom vocabularies, obtaining a total of 71 414 associations between compound prescriptions and TCM symptoms. In this way, CPMCP established the associations between TCM and modern medicine (MM) according to the associations between TCM symptoms and MM symptoms. In addition, to further exhibit the compatibility mechanism of compound prescriptions, CPMCP summarizes a set of common drug combination principles by analyzing the existing prescriptions. We believe that CPMCP can promote the modernization of TCM and make greater contributions to MM. Database URL http://cpmcp.top.
虽然已经出现了几个与中药（TCM）相关的数据库，但它们主要专注于研究单一药材，这对于临床研究和应用来说远远不够。相比之下，复方方剂在 TCM 中更具信息量和意义，因为它们除了包含关于单一药材的相对孤立的信息外，还体现了 TCM 中关于药材配伍的信息。TCM 中的配伍信息至关重要，因为它不仅传达了用于治疗特殊疾病的成分，还传达了如何组合这些单一药材。我们建立了一个中药成方和复方方剂数据库（CPMCP）。它展示了中药成方（CPM）和古方的处方信息。CPMCP 报告了它们的综合和标准化信息，如成分、适应症和禁忌症。值得一提的是，我们组织了相关专家，花费了大量时间手动将复方方剂在古中医中的功能映射到标准化的 TCM 症状词汇上，共获得了 71414 个复方方剂与 TCM 症状之间的关联。这样，CPMCP 根据 TCM 症状与 MM 症状之间的关联，建立了 TCM 与现代医学（MM）之间的关联。此外，为了进一步展示复方方剂的配伍机制，CPMCP 通过分析现有方剂总结了一套常见的药物组合原则。我们相信，CPMCP 可以促进 TCM 的现代化，并为 MM 做出更大的贡献。数据库网址：http://cpmcp.top。
