Ajmera Transplant Centre, Schwartz Reisman Liver Research Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada.
Semin Liver Dis. 2022 Aug;42(3):250-270. doi: 10.1055/s-0042-1755272. Epub 2022 Aug 25.
The human liver is a complex organ made up of multiple specialized cell types that carry out key physiological functions. An incomplete understanding of liver biology limits our ability to develop therapeutics to prevent chronic liver diseases, liver cancers, and death as a result of organ failure. Recently, single-cell modalities have expanded our understanding of the cellular phenotypic heterogeneity and intercellular cross-talk in liver health and disease. This review summarizes these findings and looks forward to highlighting new avenues for the application of single-cell genomics to unravel unknown pathogenic pathways and disease mechanisms for the development of new therapeutics targeting liver pathology. As these technologies mature, their integration into clinical data analysis will aid in patient stratification and in developing treatment plans for patients suffering from liver disease.
人类肝脏是一个由多种特化细胞类型组成的复杂器官，这些细胞类型执行着关键的生理功能。对肝脏生物学的不完全理解限制了我们开发治疗方法以预防慢性肝病、肝癌以及因器官衰竭导致的死亡的能力。最近，单细胞模式扩大了我们对肝脏健康和疾病中细胞表型异质性和细胞间串扰的理解。这篇综述总结了这些发现，并期待着强调单细胞基因组学在揭示未知的发病途径和疾病机制以开发针对肝脏病理的新治疗方法方面的新途径。随着这些技术的成熟，它们将被整合到临床数据分析中，以帮助对患者进行分层，并为患有肝病的患者制定治疗计划。
