Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Botaniczna 3, 31-503, Kraków, Poland.
Department of Otolaryngology, Jagiellonian University Medical College, Jakubowskiego 2, 30-688, Kraków, Poland.
Sci Rep. 2022 Aug 25;12(1):14492. doi: 10.1038/s41598-022-18734-3.
Nasal scraping cytology is a non-invasive tool used in the diagnostics of allergic and non-allergic rhinitis. The study aimed to analyze to what extent the cytological picture of the nasal mucosa coincides with the diagnosis of a given disease, taking into account the content of eosinophils. Retrospective analysis of the cytograms performed in 842 patients was carried out in relation to the disease entities and the content of eosinophils. Significant relationship between the Epith:Infl ratio and the four groups of diseases (Chi = 9.6488; p = .014) was confirmed. The more intensive inflammation was found, the higher percentage of patients had manifested the increased level of eosinophils (> 1% in the inflammatory cells). The value of 20% of eosinophils in all counted cells corresponds to around 45% of eosinophils in the inflammatory cells in patients with the evident inflammatory picture. Allergic rhinitis presents a different cytological picture regarding the eosinophilic reaction against the background of the inflammation process: the higher degree of inflammation observed, the lower amount of eosinophils detected, with the exception of allergic rhinitis provoked by pollen allergens.
鼻腔刮片细胞学是非侵入性工具，用于诊断过敏性和非过敏性鼻炎。本研究旨在分析鼻腔黏膜细胞学图像在多大程度上与特定疾病的诊断相符，同时考虑嗜酸性粒细胞的含量。对 842 例患者的细胞图像进行回顾性分析，与疾病实体和嗜酸性粒细胞含量有关。上皮细胞：炎症细胞比值与四组疾病之间存在显著相关性（Chi=9.6488;p=0.014）。发现炎症越强烈，表现出嗜酸性粒细胞水平升高（炎症细胞中超过 1%）的患者比例越高。在所有计数的细胞中，20%的嗜酸性粒细胞对应于炎症细胞中约 45%的嗜酸性粒细胞，在明显炎症表现的患者中。过敏性鼻炎在炎症过程中的嗜酸性粒细胞反应方面呈现出不同的细胞学图像：观察到的炎症程度越高，检测到的嗜酸性粒细胞数量越低，但花粉过敏原引起的过敏性鼻炎除外。
