Department of Cardiology, Fukushima Red Cross Hospital, Fukushima, Japan.
Department of Cardiology, Takeda General Hospital, Aizuwakamatsu, Japan.
Sci Rep. 2022 Aug 25;12(1):14554. doi: 10.1038/s41598-022-18914-1.
We aimed to clarify the relationship between apolipoprotein C3 (apo-C3) and the vascular composition of lesion plaque in stable coronary disease (SCD) before percutaneous coronary intervention (PCI), and to investigate major adverse cardiovascular events (MACEs) within 4 years. Data of 98 consecutive patients with SCD who underwent PCI between November 1, 2012, and March 10, 2015, were analyzed. Laboratory and virtual histology-intravascular ultrasound (VH-IVUS) examinations of culprit lesions were conducted before PCI. Patients were divided according to median apo-C3 into low apo-C3 (≤ 8.5 mg/dL) and high apo-C3 (> 8.5 mg/dL) groups. VH-IVUS data indicated that the percentage of necrotic core volume (%NC) was significantly higher in the high apo-C3 group than in the low apo-C3 group. Moreover, the %NC significantly correlated with the apo-C3 level (R = 0.2109, P = 0.037). Kaplan-Meier curve analysis revealed that freedom from MACEs exhibited a greater decrease in the high apo-C3 group than in the low apo-C3 group, and in the high %NC group than in the low %NC group. Multivariate Cox hazards analysis showed that the %NC and high apo-C3 were independent predictors of 4 year MACEs. Apo-C3 may be a useful marker of future MACEs in patients with SCD after PCI and contribute to %NC growth.
我们旨在明确经皮冠状动脉介入治疗 (PCI) 前稳定型冠状动脉疾病 (SCD) 患者载脂蛋白 C3 (apo-C3) 与病变斑块血管成分之间的关系，并探究 4 年内主要不良心血管事件 (MACEs)。分析了 2012 年 11 月 1 日至 2015 年 3 月 10 日期间行 PCI 的 98 例连续 SCD 患者的数据。在 PCI 前进行了病变的实验室和虚拟组织学血管内超声 (VH-IVUS) 检查。根据 apo-C3 的中位数将患者分为低 apo-C3（≤8.5mg/dL）和高 apo-C3（>8.5mg/dL）组。VH-IVUS 数据表明，高 apo-C3 组的坏死核心体积百分比（%NC）明显高于低 apo-C3 组。此外，%NC 与 apo-C3 水平显著相关（R=0.2109，P=0.037）。Kaplan-Meier 曲线分析显示，高 apo-C3 组的 MACE 无事件率下降幅度大于低 apo-C3 组，高 %NC 组的 MACE 无事件率下降幅度大于低 %NC 组。多变量 Cox 风险分析表明，%NC 和高 apo-C3 是 4 年 MACEs 的独立预测因子。apo-C3 可能是 PCI 后 SCD 患者未来 MACEs 的有用标志物，并有助于 %NC 的增长。
