Ahmad Nurulumi, Hui-Yin Yow, Makmor-Bakry Mohd
Faculty of Pharmacy, University Sultan Zainal Abidin, Terengganu, Malaysia.
Faculty of Pharmacy, Taylors University, Kuala Lumpur, Malaysia.
Pak J Pharm Sci. 2022 Jul;35(4):1043-1053.
The universal epileptogenic cascade remains unknown and most modern treatments focus on the reduction of symptoms and the prevention of seizure recurrence. Experimental studies have demonstrated that herbal medicines may act as antiepileptogenic agents. In this study, the possibilities of plants with antiepileptic properties were reviewed and discussed on their structures and related mechanism of actions. This work constituted a literature review of medicinal plants showing antiepileptic properties by literature searching in Science Direct, PubMed and Wiley Online Library. The keywords of search included epilepsy, antiepileptogenesis, antiepilepsy, natural compounds, extract, herbal medicines and medicinal plants in epilepsy treatment. Only articles published in English were reviewed. Mechanism of action of the natural plants were described according to experimental studies. From the databases, we found 135 natural plants with antiepileptic properties. In this review, the highly studied natural plants were selected. These included Acorus calamus, Bacopa monnieri, Boerhaavia diffusa, Curcuma longa, Gastrodia elata, Ginseng, Uncaria rhynchophylla, Pinellia ternatae, Withania somnifera, Magnolia bark and Resveratrol-related products. From the evidences, natural products may potentially be developed as antiepileptic or antiepileptogenic agents. However, several issues in drug development should be considered such as safety, formulations, pharmacokinetic characteristics and possible interactions.
普遍的致痫级联反应仍然未知，并且大多数现代治疗方法专注于减轻症状和预防癫痫复发。实验研究表明，草药可能作为抗癫痫剂发挥作用。在本研究中，对具有抗癫痫特性的植物的可能性进行了综述，并讨论了它们的结构和相关作用机制。这项工作通过在科学Direct、PubMed和Wiley在线图书馆中进行文献检索，对显示出抗癫痫特性的药用植物进行了文献综述。检索关键词包括癫痫、抗癫痫发生、抗癫痫、天然化合物、提取物、草药和癫痫治疗中的药用植物。仅对英文发表的文章进行了综述。根据实验研究描述了天然植物的作用机制。从数据库中，我们发现了135种具有抗癫痫特性的天然植物。在本综述中，选择了研究较多的天然植物。这些包括菖蒲、假马齿苋、白花蛇舌草、姜黄、天麻、人参、钩藤、半夏、印度人参、厚朴和白藜芦醇相关产品。从证据来看，天然产物可能有潜力被开发为抗癫痫或抗癫痫发生剂。然而，在药物开发中应考虑几个问题，如安全性、制剂、药代动力学特征和可能的相互作用。
