Roustaei Bahar, Zarezadeh Somayeh, Ghotbi-Ravandi Ali Akbar
Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
Neurol Sci. 2023 Dec;44(12):4291-4306. doi: 10.1007/s10072-023-07010-5. Epub 2023 Aug 15.
Epilepsy is considered common neurological diseases that threaten the lives of millions of people all around the world. Since ancient times, different forms of medications have been used to treat this condition. Adverse events associated with treatments and the residence time of available drugs caused to search for safer and more efficient therapies and drugs remain one of the major areas of research interest for scientists. As one of the therapeutics with fewer side effects, plants and their essential oils can be considered replacements for existing treatments. Medicinal plants have proven to be an effective natural source of antiepileptic drugs; most of them have their mechanism of action by affecting GABA receptors in different paths. Cannabis indica and Cymbopogon winterianus are well-known plant species with antiepileptic activities. The current review presenting a list of plants with antiepileptic effects aims to pave the way for finding alternative drugs with fewer side effects for scientists.
癫痫被认为是一种常见的神经系统疾病，威胁着全球数百万人的生命。自古以来，人们就使用不同形式的药物来治疗这种疾病。与治疗相关的不良事件以及现有药物的停留时间促使人们寻找更安全、更有效的疗法和药物，这仍然是科学家们主要的研究兴趣领域之一。作为副作用较少的治疗方法之一，植物及其精油可以被视为现有治疗方法的替代品。药用植物已被证明是抗癫痫药物的有效天然来源；它们中的大多数通过不同途径影响GABA受体来发挥作用机制。印度大麻和柠檬香茅是具有抗癫痫活性的著名植物物种。本综述列出了具有抗癫痫作用的植物，旨在为科学家们寻找副作用更少的替代药物铺平道路。
