University of Houston, College of Optometry, Houston, TX 77204, USA.
Department of Ophthalmology, Division for Dry-Eye and Ocular GvHD, Medical Faculty, University of Cologne, 50937 Cologne, Germany.
Int J Mol Sci. 2019 Jul 17;20(14):3505. doi: 10.3390/ijms20143505.
Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease and loss of ocular surface homeostasis. Increasingly, several observational clinical studies suggest that dyslipidemia (elevated blood cholesterol, triglyceride or lipoprotein levels) can initiate the development of MGD. However, conclusive evidence is lacking, and an experimental approach using a suitable model is necessary to interrogate the relationship between dyslipidemia and MGD. This systematic review discusses current knowledge on the associations between dyslipidemia and MGD. We briefly introduce a diet-induced obesity model where mice develop dyslipidemia, which can serve as a potential tool for investigating the effects of dyslipidemia on the meibomian gland. Finally, the utility of lipidomics to examine the link between dyslipidemia and MGD is considered.
睑板腺功能障碍（MGD）是干眼症和眼表面稳态丧失的主要原因。越来越多的观察性临床研究表明，血脂异常（血液胆固醇、甘油三酯或脂蛋白水平升高）可能引发 MGD 的发展。然而，目前还缺乏确凿的证据，需要使用合适的模型进行实验方法来探讨血脂异常与 MGD 之间的关系。本系统评价讨论了血脂异常与 MGD 之间关联的现有知识。我们简要介绍了一种饮食诱导肥胖模型，其中小鼠会出现血脂异常，这可能成为研究血脂异常对睑板腺影响的潜在工具。最后，还考虑了脂质组学在检查血脂异常与 MGD 之间联系的应用。
