Zheng Sisi, Song Nan, Wang Sici, Ning Yanzhe, Zhu Hong, Song Mingkang, Jia Yuan, Jia Hongxiao
The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100088, China.
Brain Sci. 2022 Aug 21;12(8):1112. doi: 10.3390/brainsci12081112.
Non-invasive brain stimulation seems to be beneficial for DPD patients. However, the sites used in previous studies were empirical. Exploring new stimulation locations via functional magnetic resonance imaging may improve the efficacy.
The objective was to find potential locations for non-invasive brain stimulation on the depersonalization-derealization disorder.
We explored the potential brain surface regions from three pipelines: pipeline 1: activation likelihood estimation meta-analysis (five studies with 36 foci included); pipeline 2: functional connectivity analysis based on DPD-network (76 subjects included); and pipeline 3: functional connectivity analysis based on DPD regions of interest from the meta-analysis. Potential targets were the 10-20 system coordinates for brain surface regions.
We identified several potential brain surface regions, including the bilateral medial prefrontal cortex, dorsal lateral prefrontal cortex, superior parietal gyrus, superior temporal gyrus, and right ventrolateral prefrontal cortex as potential sites.
Our findings of the potential stimulation targets might help clinicians optimize the application of non-invasive brain stimulation therapy in individuals with DPD.
非侵入性脑刺激似乎对人格解体障碍（DPD）患者有益。然而，先前研究中使用的部位是凭经验确定的。通过功能磁共振成像探索新的刺激位置可能会提高疗效。
目的是找到人格解体-现实解体障碍非侵入性脑刺激的潜在位置。
我们从三条途径探索潜在的脑表面区域：途径1：激活可能性估计荟萃分析（纳入五项研究，共36个病灶）；途径2：基于DPD网络的功能连接分析（纳入76名受试者）；途径3：基于荟萃分析中DPD感兴趣区域的功能连接分析。潜在靶点是脑表面区域的10-20系统坐标。
我们确定了几个潜在的脑表面区域，包括双侧内侧前额叶皮质、背外侧前额叶皮质、顶上叶、颞上回和右侧腹外侧前额叶皮质作为潜在部位。
我们对潜在刺激靶点的研究结果可能有助于临床医生优化非侵入性脑刺激疗法在DPD患者中的应用。
