Oravcova Henrieta, Katrencikova Barbora, Garaiova Iveta, Durackova Zdenka, Trebaticka Jana, Jezova Daniela
Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska Cesta 9, 84505 Bratislava, Slovakia.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Odbojarov 10, 83104 Bratislava, Slovakia.
Antioxidants (Basel). 2022 Aug 10;11(8):1546. doi: 10.3390/antiox11081546.
Late childhood and adolescence are crucial periods of brain development with high vulnerability to environmental insults. The aim of this study was to test the hypotheses that in adolescents with depression (a) 12 weeks-supplementation with omega-3 fatty acids results in the attenuation of salivary stress hormone concentrations; (b) the mentioned supplementation improves potentially disrupted daily rhythm of stress hormones; (c) stress hormone concentrations correlate with values of selected markers of oxidative stress. The sample consisted of 60 patients suffering from depression aged 11-18 years. Hormone concentrations in saliva were measured in the morning and midday before (baseline) and after (6, 12 weeks) food supplementation with omega-3 or omega-6 (as comparator) fatty acids. Morning cortisol decreased in response to omega-3 but not omega-6 fatty acids at 12 weeks compared to baseline. No changes were observed in aldosterone concentrations. The obtained results show that adolescent children with depression preserved the daily rhythm of both stress hormones. Baseline morning cortisol concentrations correlated positively with depression severity and lipoperoxides, and negatively with docosahexaenoic acid. Aldosterone concentrations correlated positively with 8-isoprostane. Thus, both hormones showed positive correlation with the selected markers of oxidative stress suggesting that enhanced stress hormone secretion may be associated with increased oxidative tissue damage in adolescent children with depression. This study was registered with the ISRCTN registry (DEPOXIN study, ISRCTN81655012).
儿童晚期和青少年时期是大脑发育的关键阶段，极易受到环境侵害。本研究的目的是检验以下假设：在患有抑郁症的青少年中，（a）补充12周的omega-3脂肪酸可导致唾液应激激素浓度降低；（b）上述补充可改善可能被打乱的应激激素日常节律；（c）应激激素浓度与所选氧化应激标志物的值相关。样本包括60名年龄在11至18岁之间的抑郁症患者。在补充omega-3或omega-6（作为对照）脂肪酸的食物之前（基线）以及之后（6周、12周），于早晨和中午测量唾液中的激素浓度。与基线相比，12周时omega-3脂肪酸可使早晨皮质醇降低，而omega-6脂肪酸则无此作用。醛固酮浓度未观察到变化。所得结果表明，患有抑郁症的青少年儿童保持了两种应激激素的日常节律。基线早晨皮质醇浓度与抑郁严重程度和脂质过氧化物呈正相关，与二十二碳六烯酸呈负相关。醛固酮浓度与8-异前列腺素呈正相关。因此，两种激素均与所选氧化应激标志物呈正相关，这表明在患有抑郁症的青少年儿童中，应激激素分泌增加可能与氧化组织损伤增加有关。本研究已在ISRCTN注册中心注册（DEPOXIN研究，ISRCTN81655012）。
