• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

家兔的性状分析（使用简化基因组测序数据中的SNP标记）

Trait Analysis in Domestic Rabbits ( Using SNP Markers from Genotyping-by-Sequencing Data.

作者信息

Li Congyan, Li Yuying, Zheng Jie, Guo Zhiqiang, Mei Xiuli, Lei Min, Ren Yongjun, Zhang Xiangyu, Zhang Cuixia, Yang Chao, Tang Li, Ji Yang, Yang Rui, Yu Jifeng, Xie Xiaohong, Kuang Liangde

机构信息

Animal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, Chengdu 610066, China.

Sichuan Academy of Agricultural Sciences, Chengdu 610066, China.

出版信息

Animals (Basel). 2022 Aug 11;12(16):2052. doi: 10.3390/ani12162052.

DOI:10.3390/ani12162052
PMID:36009642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9404428/
Abstract

The domestic rabbit () is a very important variety in biomedical research and agricultural animal breeding. Due to the different geographical areas in which rabbit breeds originated, and the long history of domestication/artificial breeding, rabbits have experienced strong selection pressure, which has shaped many traits of most rabbit varieties, such as color and weight. An efficient genome-wide single-nucleotide polymorphism (SNP) detection strategy is genotyping-by-sequencing (GBS), which has been widely used in many organisms. This study attempted to explore bi-allelic SNPs associated with fur color and weight-related traits using GBS in five rabbit breeds. The data consisted of a total 831,035 SNPs in 150 individuals from Californian rabbits (CF), German Zika rabbits (ZK), Qixing rabbits (QX), Sichuan grey rabbits (SG), and Sichuan white rabbits (SW). In addition, these five breeds of rabbits were obviously independent populations, with high genetic differentiation among breeds and low genetic diversity within breeds. A total of 32,144 SNP sites were identified by selective sweep among the different varieties. The genes that carried SNP loci in these selected regions were related to important traits (fur color and weight) and signal pathways, such as the MAPK/ERK signaling pathway and the Hippo signaling pathway. In addition, genes related to fur color and weight were identified, such as , and , , , and , and they had more SNP sites. The research offers the foundation for further exploration of molecular genetic markers of SNPs that are related to traits.

摘要

家兔是生物医学研究和农业家畜育种中非常重要的品种。由于家兔品种起源的地理区域不同，以及驯化/人工育种历史悠久，家兔经历了强大的选择压力，这塑造了大多数家兔品种的许多性状，如毛色和体重。一种高效的全基因组单核苷酸多态性（SNP）检测策略是简化基因组测序（GBS），它已在许多生物体中广泛应用。本研究试图使用GBS在五个家兔品种中探索与毛色和体重相关性状的双等位基因SNP。数据包括来自加利福尼亚兔（CF）、德国齐卡兔（ZK）、七星兔（QX）、四川灰兔（SG）和四川白兔（SW）的150个个体中的总共831,035个SNP。此外，这五个家兔品种明显是独立的群体，品种间遗传分化高，品种内遗传多样性低。通过在不同品种间的选择性清除共鉴定出32,144个SNP位点。在这些选定区域携带SNP位点的基因与重要性状（毛色和体重）及信号通路相关，如MAPK/ERK信号通路和Hippo信号通路。此外，还鉴定出了与毛色和体重相关的基因，如……，它们有更多的SNP位点。该研究为进一步探索与性状相关的SNP分子遗传标记提供了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d3/9404428/fa2d19f35cd9/animals-12-02052-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d3/9404428/c58f5591b87d/animals-12-02052-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d3/9404428/70e8e6c73f14/animals-12-02052-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d3/9404428/f6bc802c09fd/animals-12-02052-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d3/9404428/d8c72e10b234/animals-12-02052-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d3/9404428/fa2d19f35cd9/animals-12-02052-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d3/9404428/c58f5591b87d/animals-12-02052-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d3/9404428/70e8e6c73f14/animals-12-02052-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d3/9404428/f6bc802c09fd/animals-12-02052-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d3/9404428/d8c72e10b234/animals-12-02052-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d3/9404428/fa2d19f35cd9/animals-12-02052-g005.jpg

相似文献

1
Trait Analysis in Domestic Rabbits ( Using SNP Markers from Genotyping-by-Sequencing Data.家兔的性状分析（使用简化基因组测序数据中的SNP标记）
Animals (Basel). 2022 Aug 11;12(16):2052. doi: 10.3390/ani12162052.
2
Genomic diversity and signatures of selection in meat and fancy rabbit breeds based on high-density marker data.基于高密度标记数据的肉兔和观赏兔品种的基因组多样性和选择特征。
Genet Sel Evol. 2022 Jan 21;54(1):3. doi: 10.1186/s12711-022-00696-9.
3
Resequencing Analyses Revealed Genetic Diversity and Selection Signatures during Rabbit Breeding and Improvement.重测序分析揭示了家兔育种与改良过程中的遗传多样性和选择印记。
Genes (Basel). 2024 Mar 29;15(4):433. doi: 10.3390/genes15040433.
4
Population genomic structures and signatures of selection define the genetic uniqueness of several fancy and meat rabbit breeds.群体基因组结构和选择特征定义了几种观赏兔和肉兔品种的遗传独特性。
J Anim Breed Genet. 2023 Nov;140(6):663-678. doi: 10.1111/jbg.12818. Epub 2023 Jul 12.
5
Rabbits - their domestication and molecular genetics of hair coat development and quality.家兔的驯化及其毛发生长和品质的分子遗传学
Anim Genet. 2021 Feb;52(1):10-20. doi: 10.1111/age.13024. Epub 2020 Nov 20.
6
The genetic structure of domestic rabbits.家兔的遗传结构。
Mol Biol Evol. 2011 Jun;28(6):1801-16. doi: 10.1093/molbev/msr003. Epub 2011 Jan 7.
7
A genome-wide association study for the number of teats in European rabbits (Oryctolagus cuniculus) identifies several candidate genes affecting this trait.一项针对欧洲兔（Oryctolagus cuniculus）乳头数量的全基因组关联研究确定了几个影响该性状的候选基因。
Anim Genet. 2021 Apr;52(2):237-243. doi: 10.1111/age.13036. Epub 2021 Jan 11.
8
High-throughput SNP discovery in the rabbit (Oryctolagus cuniculus) genome by next-generation semiconductor-based sequencing.高通量 SNP 在兔（Oryctolagus cuniculus）基因组中的发现通过下一代基于半导体的测序技术。
Anim Genet. 2014 Apr;45(2):304-7. doi: 10.1111/age.12121. Epub 2014 Jan 21.
9
A genome-wide association study of coat color in Chinese Rex rabbits.中国獭兔毛色的全基因组关联研究。
Front Vet Sci. 2023 Aug 16;10:1184764. doi: 10.3389/fvets.2023.1184764. eCollection 2023.
10
Use of genotyping-by-sequencing to determine the genetic structure in the medicinal plant chamomile, and to identify flowering time and alpha-bisabolol associated SNP-loci by genome-wide association mapping.利用测序基因分型来确定药用植物洋甘菊的遗传结构，并通过全基因组关联图谱鉴定开花时间和与α-红没药醇相关的单核苷酸多态性位点。
BMC Genomics. 2017 Aug 10;18(1):599. doi: 10.1186/s12864-017-3991-0.

引用本文的文献

1
Transcriptome-wide association studies identify candidate genes for carcass and meat traits in meat rabbits.全转录组关联研究确定了肉兔胴体和肉质性状的候选基因。
Front Vet Sci. 2024 Dec 6;11:1453196. doi: 10.3389/fvets.2024.1453196. eCollection 2024.

本文引用的文献

1
Editing MC1R in human melanoma cells by CRISPR/Cas9 and functional analysis.通过 CRISPR/Cas9 编辑人类黑色素瘤细胞中的 MC1R 并进行功能分析。
Yi Chuan. 2022 Jul 20;44(7):581-590. doi: 10.16288/j.yczz.22-037.
2
Genetics of Base Coat Colour Variations and Coat Colour-Patterns of the South African Nguni Cattle Investigated Using High-Density SNP Genotypes.利用高密度单核苷酸多态性（SNP）基因型对南非恩古尼牛基础毛色变异和毛色图案的遗传学研究
Front Genet. 2022 Jun 7;13:832702. doi: 10.3389/fgene.2022.832702. eCollection 2022.
3
Assessment the effect of genomic selection and detection of selective signature in broilers.
评估基因组选择对肉鸡的影响和检测选择信号。
Poult Sci. 2022 Jun;101(6):101856. doi: 10.1016/j.psj.2022.101856. Epub 2022 Mar 12.
4
Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice.极低蛋白饮食导致食物摄入量减少和体重减轻，这与抑制小鼠下丘脑中的 mTOR 信号有关。
Cell Metab. 2021 May 4;33(5):888-904.e6. doi: 10.1016/j.cmet.2021.01.017. Epub 2021 Mar 4.
5
Genome-wide Meta-analysis Finds the ACSL5-ZDHHC6 Locus Is Associated with ALS and Links Weight Loss to the Disease Genetics.全基因组荟萃分析发现 ACSL5-ZDHHC6 基因座与 ALS 相关，并将体重减轻与疾病遗传联系起来。
Cell Rep. 2020 Oct 27;33(4):108323. doi: 10.1016/j.celrep.2020.108323.
6
Comparative analysis of host resistance to Sarcoptes scabiei var. cuniculi in two different rabbit breeds.两种不同兔种对兔疥螨的宿主抗性比较分析。
Parasit Vectors. 2019 Nov 8;12(1):530. doi: 10.1186/s13071-019-3764-5.
7
An Evaluation of the Genetic Structure of Geese Maintained in Poland on the Basis of Microsatellite Markers.基于微卫星标记对波兰养殖鹅的遗传结构评估
Animals (Basel). 2019 Sep 27;9(10):737. doi: 10.3390/ani9100737.
8
Genetic diversity and population structure of four Chinese rabbit breeds.四个中国兔品种的遗传多样性和种群结构。
PLoS One. 2019 Sep 16;14(9):e0222503. doi: 10.1371/journal.pone.0222503. eCollection 2019.
9
fastp: an ultra-fast all-in-one FASTQ preprocessor.fastp：一个超快速的一体化 FASTQ 预处理程序。
Bioinformatics. 2018 Sep 1;34(17):i884-i890. doi: 10.1093/bioinformatics/bty560.
10
RabGTD: a comprehensive database of rabbit genome and transcriptome.RabGTD：一个兔基因组和转录组的综合数据库。
Database (Oxford). 2018 Jan 1;2018. doi: 10.1093/database/bay075.