扎加齐格大学医院重症监护病房分离出的耐碳青霉烯类细菌的特性分析

Gandor Nessma Hessin Mohamed, Amr Ghada El-Sayed, Eldin Algammal Sahar Mohamed Saad, Ahmed Alshymaa Abdullah

Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Alsharquia 44519, Egypt.

Department of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Zagazig University, Alsharquia 44519, Egypt.

Antibiotics (Basel). 2022 Aug 16;11(8):1108. doi: 10.3390/antibiotics11081108.

The advent of carbapenem-resistant (CRKP) poses a significant challenge to public health, as carbapenems are typically employed as a last resort to treat nosocomial infections caused by such organisms, especially in intensive care units (ICUs). This study aims to characterize the CRKP isolated from patients admitted to the Zagazig University Hospitals (ZUHs) ICU in Egypt. About 56.2%, 41.0%, and 32.4% of the isolates indicated the presence of , , and , respectively. Carbapenemase-encoding genes were found in many isolates, and was the most predominant gene. Nevertheless, this situation has become a heavy burden in developing countries, including Egypt, and is associated with substantial morbidity, mortality, and increased healthcare expenses.

耐碳青霉烯类肺炎克雷伯菌（CRKP）的出现对公共卫生构成了重大挑战，因为碳青霉烯类药物通常被用作治疗由此类微生物引起的医院感染的最后手段，尤其是在重症监护病房（ICU）。本研究旨在对从埃及扎加齐格大学医院（ZUHs）ICU收治的患者中分离出的CRKP进行特征分析。分别有大约56.2%、41.0%和32.4%的分离株显示存在……、……和……。在许多分离株中发现了碳青霉烯酶编码基因，且……是最主要的基因。然而，这种情况在包括埃及在内的发展中国家已成为沉重负担，并与大量发病、死亡以及医疗费用增加相关。