Guardado Kathia, Varela-Cardoso Miguel, Pérez-Roa Verónica Ofelia, Morales-Romero Jaime, Zenteno-Cuevas Roberto, Ramos-Ligonio Ángel, Guzmán-Martínez Oscar, Sampieri Clara L, Ortiz-Chacha Christian S, Pérez-Varela Rosybet, Mora-Turrubiate Cristina Fernanda, Montero Hilda
Instituto de Salud Pública, Universidad Veracruzana, Xalapa 91090, Mexico.
Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa 91090, Mexico.
Children (Basel). 2022 Aug 12;9(8):1216. doi: 10.3390/children9081216.
Zika virus (ZIKV) infection in pregnancy is associated with birth and developmental alterations in infants. In this study, clinical records of 47 infants whose mothers had Zika during pregnancy or clinical manifestations compatible with Zika were reviewed. A description of the infants' anomalies was established, and a neurodevelopmental assessment was performed on 18 infants, using the Evaluation of Infant Development (EDI for its initialism in Spanish) and DDST-II (Denver Developmental Screening Test II) tests. From his sample, 74.5% of the infants evaluated had major anomalies and 51.9% had minor anomalies. The incidence of major anomalies, related to trimester of pregnancy, was 84.2% for the first trimester, 77.8% for the second trimester, and 37.5% in the third trimester. A similar trend was observed in the frequency of infants without anomalies and was less evident in the incidence of minor anomalies ( = 0.016). Through neurodevelopmental assessments, EDI identified 27.8% of infants as having normal development, while 55.5% of affected infants had developmental delay, and 16.7% were at risk for developmental delay. The DDSST-II showed that 77.7% infants had delay in the gross motor and language area, 88.8% in the fine-adaptative motor area, and 72.2% in the personal-social area. In this work, children of mothers with ZIKV infection during pregnancy may have major or minor anomalies regardless of the trimester of pregnancy in which the infection occurred. The neurodevelopmental assessment shows that ZIKV can cause a developmental delay in infants with the fine-adaptative motor area being the most affected.
孕期感染寨卡病毒（ZIKV）与婴儿出生及发育异常有关。在本研究中，对47名母亲在孕期感染寨卡病毒或有寨卡病毒相关临床表现的婴儿的临床记录进行了回顾。确定了婴儿异常情况的描述，并对18名婴儿进行了神经发育评估，采用婴儿发育评估（EDI，西班牙语首字母缩写）和丹佛发育筛查测试II（DDST-II）。在该样本中，74.5%接受评估的婴儿有严重异常，51.9%有轻微异常。与妊娠 trimester相关的严重异常发生率，孕早期为84.2%，孕中期为77.8%，孕晚期为37.5%。在无异常婴儿的频率上也观察到类似趋势，而在轻微异常发生率上不太明显（ = 0.016）。通过神经发育评估，EDI确定27.8%的婴儿发育正常，而55.5%的受影响婴儿有发育迟缓，16.7%有发育迟缓风险。DDST-II显示，77.7%的婴儿在大运动和语言领域有延迟，88.8%在精细适应运动领域有延迟，72.2%在个人社交领域有延迟。在这项研究中，孕期感染ZIKV的母亲所生儿童无论感染发生在妊娠的哪个 trimester，都可能有严重或轻微异常。神经发育评估表明，ZIKV可导致婴儿发育迟缓，其中精细适应运动领域受影响最大。
