Lee Jae Min, Kim Jong Bum, Byun Dong Hyun, Son Su Min
Department of Pediatric Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea.
Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu 42415, Korea.
Children (Basel). 2022 Aug 12;9(8):1223. doi: 10.3390/children9081223.
Three patients who exhibited hemiplegic symptoms on conventional brain magnetic resonance imaging (MRI), during maintenance treatment for acute lymphoblastic leukemia, are reported. All patients exhibited unilateral motor weakness and poor hand function during chemotherapy. Conventional MRI revealed no definite abnormal lesions. However, in diffusion tensor tractography, the affected corticospinal tract on the contralateral side, consistently with clinical dysfunction, revealed disrupted integrity, decreased fractional anisotropy, and increased apparent diffusion coefficient compared to the results of the unaffected side or control participants. Control participants matched for age, sex, and duration from leukemia diagnosis, who underwent chemotherapy but had no motor impairments, exhibited preserved integrity of both corticospinal tracts. Diffusion tensor tractography can help evaluate patients with acute lymphoblastic leukemia and neurological dysfunction.
本文报告了3例在急性淋巴细胞白血病维持治疗期间，常规脑磁共振成像（MRI）显示偏瘫症状的患者。所有患者在化疗期间均出现单侧运动无力和手部功能不佳。常规MRI未发现明确的异常病变。然而，在扩散张量纤维束成像中，与临床功能障碍一致，患侧对侧的皮质脊髓束显示完整性破坏、各向异性分数降低以及表观扩散系数增加，与未受影响侧或对照参与者的结果相比。年龄、性别和白血病诊断后的病程相匹配，接受化疗但无运动障碍的对照参与者，其双侧皮质脊髓束完整性保留。扩散张量纤维束成像有助于评估急性淋巴细胞白血病和神经功能障碍患者。
