Pastore Marco R, Grotto Alberto, Vezzoni Francesca, Gaggino Andrea, Milan Serena, Gouigoux Stefano, Guerin Pier Luigi, Vinciguerra Alex L, Cirigliano Gabriella, Tognetto Daniele
Eye Clinic, Department of Medicine, Surgery and Health Sciences, University of Trieste, 34129 Trieste, Italy.
Diagnostics (Basel). 2022 Aug 7;12(8):1908. doi: 10.3390/diagnostics12081908.
Purpose: to investigate the reproducibility and reliability of OCT-A vascular measurements using Heidelberg Spectralis II OCT-A. Methods: a prospective study involving a single eye of patients aged 18 or older with no ocular disease. In order to investigate the reliability of the first and second OCT-A scans, the coefficient of variation of the foveal avascular zone (FAZ) and the vessel density (VD) in the superficial (SCP), intermediate (ICP) and deep capillary plexus (DCP) were calculated. Results: A total of 75 eyes were included in the study. The mean FAZ in the first and second scan was 0.36 × 0.13 mm2 and 0.37 × 0.12 mm2, respectively, in the SCP, 0.23 × 0.10 mm2 and 0.23 × 0.09 mm2 in the ICP, and 0.42 × 0.11 mm2 and 0.43 × 0.12 mm2 in the DCP. The overall VD was 36.05 × 9.01 and 35.33 × 9.92 at the first and second scan, respectively, in the SCP, 21.87 × 5.00 and 21.32 × 5.56 in the ICP, and 23.84 × 6.53 and 23.20 × 6.83 in the DCP. No statistically significant differences in FAZ measurements and VD in all sectors of each capillary plexus were observed between the first and second scan (p > 0.05). Conclusion: our study demonstrated the good reproducibility and reliability of OCT-A vascular measurements in the analysis of the FAZ and the quantification of VD in each capillary plexus of the retina.
使用海德堡Spectralis II OCT-A研究光学相干断层扫描血管造影（OCT-A）血管测量的可重复性和可靠性。方法：一项前瞻性研究，纳入18岁及以上无眼部疾病患者的单眼。为了研究首次和第二次OCT-A扫描的可靠性，计算了中央凹无血管区（FAZ）以及浅层毛细血管丛（SCP）、中间层毛细血管丛（ICP）和深层毛细血管丛（DCP）的血管密度（VD）的变异系数。结果：该研究共纳入75只眼。在SCP中，首次和第二次扫描时FAZ的平均值分别为0.36×0.13mm²和0.37×0.12mm²，在ICP中分别为0.23×0.10mm²和0.23×0.09mm²，在DCP中分别为0.42×0.11mm²和0.43×0.12mm²。在SCP中，首次和第二次扫描时总体VD分别为36.05×9.01和35.33×9.92，在ICP中分别为21.87×5.00和21.32×5.56，在DCP中分别为23.84×6.53和23.20×6.83。首次和第二次扫描之间，各毛细血管丛所有区域的FAZ测量值和VD均未观察到统计学上的显著差异（p>0.05）。结论：我们的研究表明，在分析视网膜各毛细血管丛的FAZ和量化VD方面，OCT-A血管测量具有良好的可重复性和可靠性。
