Lupidi Marco, Coscas Florence, Cagini Carlo, Fiore Tito, Spaccini Elisa, Fruttini Daniela, Coscas Gabriel
Centre de l'Odéon, Paris, France; Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy.
Centre de l'Odéon, Paris, France; Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Université Paris Est, Créteil, France.
Am J Ophthalmol. 2016 Sep;169:9-23. doi: 10.1016/j.ajo.2016.06.008. Epub 2016 Jun 11.
To describe a new automated quantitative technique for displaying and analyzing macular vascular perfusion using optical coherence tomography angiography (OCT-A) and to determine a normative data set, which might be used as reference in identifying progressive changes due to different retinal vascular diseases.
Reliability study.
A retrospective review of 47 eyes of 47 consecutive healthy subjects imaged with a spectral-domain OCT-A device was performed in a single institution. Full-spectrum amplitude-decorrelation angiography generated OCT angiograms of the retinal superficial and deep capillary plexuses. A fully automated custom-built software was used to provide quantitative data on the foveal avascular zone (FAZ) features and the total vascular and avascular surfaces. A comparative analysis between central macular thickness (and volume) and FAZ metrics was performed. Repeatability and reproducibility were also assessed in order to establish the feasibility and reliability of the method.
The comparative analysis between the superficial capillary plexus and the deep capillary plexus revealed a statistically significant difference (P < .05) in terms of FAZ perimeter, surface, and major axis and a not statistically significant difference (P > .05) when considering total vascular and avascular surfaces. A linear correlation was demonstrated between central macular thickness (and volume) and the FAZ surface. Coefficients of repeatability and reproducibility were less than 0.4, thus demonstrating high intraobserver repeatability and interobserver reproducibility for all the examined data.
A quantitative approach on retinal vascular perfusion, which is visible on Spectralis OCT angiography, may offer an objective and reliable method for monitoring disease progression in several retinal vascular diseases.
描述一种使用光学相干断层扫描血管造影（OCT-A）显示和分析黄斑血管灌注的新型自动化定量技术，并确定一个规范性数据集，该数据集可作为识别不同视网膜血管疾病所致进展性变化的参考。
可靠性研究。
在单一机构对47例连续健康受试者的47只眼进行回顾性研究，这些眼睛使用光谱域OCT-A设备成像。全谱振幅去相关血管造影生成视网膜浅层和深层毛细血管丛的OCT血管造影图像。使用一个完全自动化的定制软件提供关于黄斑无血管区（FAZ）特征以及总血管和无血管表面的定量数据。对中心黄斑厚度（和体积）与FAZ指标进行比较分析。还评估了重复性和再现性，以确定该方法的可行性和可靠性。
浅层毛细血管丛和深层毛细血管丛之间的比较分析显示，在FAZ周长、面积和长轴方面存在统计学显著差异（P < 0.05），而在考虑总血管和无血管表面时差异无统计学意义（P > 0.05）。中心黄斑厚度（和体积）与FAZ面积之间呈线性相关。重复性和再现性系数均小于0.4，因此所有检查数据均显示出高观察者内重复性和观察者间再现性。
光谱域OCT血管造影中可见的视网膜血管灌注定量方法，可能为监测多种视网膜血管疾病的疾病进展提供一种客观可靠的方法。
