Lin Chia-Ju, Liu Chih-Ku, Hsieh Hsiao-Yun, Chen Ming-Jer, Tsai Ching-Pei
Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Diagnostics (Basel). 2022 Aug 19;12(8):2009. doi: 10.3390/diagnostics12082009.
(1) Background: Limited data showed changes in glomerulation in the bladder mucosa of patients with interstitial cystitis (IC) after intravesical hyaluronic acid (HA) bladder infusion. We aimed to investigate the above changes. (2) Methods: Medical records of IC patients were reviewed retrospectively, from January 2010 to October 2019. Patients who had received repeated cystoscopy after intravesical HA treatment were enrolled. The associations of multiple parameters, including the ages, symptoms, initial glomerulation stage, HA doses, and the interval period of repeated cystoscopy between the glomerulation change in the repeated cystoscopy were analyzed. (3) Results: Among the 35 patients, 9 cases (25.7%) showed better glomerulation grades in the repeated cystoscope (Group 1), 20 cases (57.1%) showed the same grades (Group 2), and 6 cases showed worse grades (Group 3). No difference was seen in the initial grades or treatment course among the three groups. The interval periods from the initial to the repeated cystoscopy of Group 1 were longer than Group 2 and Group 3 ( = 0.031). Group 3 presents an elder age trend than the other two groups. (4) Conclusion: Intravesical HA repaired bladder glomerulation in a small group of patients with IC. Prolonged treatment has potential benefits, while older age is possibly a negative factor. However, no strong correlation was found between the initial glomerulation grades or changes in glomerulation grades with clinical symptoms.
(1) 背景：有限的数据显示，膀胱内注入透明质酸（HA）后，间质性膀胱炎（IC）患者膀胱黏膜的肾小球化发生了变化。我们旨在研究上述变化。(2) 方法：回顾性分析2010年1月至2019年10月IC患者的病历。纳入接受膀胱内HA治疗后接受多次膀胱镜检查的患者。分析了多个参数之间的关联，包括年龄、症状、初始肾小球化阶段、HA剂量以及重复膀胱镜检查之间肾小球化变化的间隔时间。(3) 结果：35例患者中，9例（25.7%）在重复膀胱镜检查中显示肾小球化等级改善（第1组），20例（57.1%）显示等级相同（第2组），6例显示等级变差（第3组）。三组之间在初始等级或治疗过程方面未见差异。第1组从初始到重复膀胱镜检查的间隔时间长于第2组和第3组（P = 0.031）。第3组呈现出比其他两组年龄更大的趋势。(4) 结论：膀胱内HA修复了一小部分IC患者的膀胱肾小球化。延长治疗有潜在益处，而年龄较大可能是一个负面因素。然而，初始肾小球化等级或肾小球化等级变化与临床症状之间未发现强相关性。
