Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium.
Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, 6708WE Wageningen, The Netherlands.
Cells. 2022 Aug 16;11(16):2534. doi: 10.3390/cells11162534.
The reward system involved in hedonic food intake presents neuronal and behavioral dysregulations during obesity. Moreover, gut microbiota dysbiosis during obesity promotes low-grade inflammation in peripheral organs and in the brain contributing to metabolic alterations. The mechanisms underlying reward dysregulations during obesity remain unclear. We investigated if inflammation affects the striatum during obesity using a cohort of control-fed or diet-induced obese (DIO) male mice. We tested the potential effects of specific gut bacteria on the reward system during obesity by administrating daily or a placebo to DIO male mice. We showed that dysregulations of the food reward are associated with inflammation and alterations in the blood-brain barrier in the striatum of obese mice. We identified as a novel actor able to improve the dysregulated reward behaviors associated with obesity, potentially through a decreased activation of inflammatory pathways and lipid-sensing ability in the striatum. These results open a new field of research and suggest that gut microbes can be considered as an innovative therapeutic approach to attenuate reward alterations in obesity. This study provides substance for further investigations of -mediated behavioral improvements in other inflammatory neuropsychiatric disorders.
在肥胖症期间，参与享乐性食物摄入的奖励系统表现出神经元和行为失调。此外，肥胖症期间的肠道微生物失调会促进外周器官和大脑中的低度炎症，从而导致代谢改变。奖励失调的机制在肥胖症期间仍然不清楚。我们使用一组对照喂养或饮食诱导肥胖（DIO）雄性小鼠研究了炎症是否在肥胖症期间影响纹状体。我们通过每天或安慰剂给 DIO 雄性小鼠给药，测试了特定肠道细菌对肥胖症期间奖励系统的潜在影响。我们表明，食物奖励的失调与肥胖小鼠纹状体中的炎症和血脑屏障的改变有关。我们确定 是一种新的能够改善与肥胖相关的失调奖励行为的因子，可能是通过降低纹状体中炎症途径和脂质感知能力的激活。这些结果开辟了一个新的研究领域，并表明肠道微生物可以被认为是一种创新的治疗方法，以减轻肥胖症中的奖励改变。本研究为进一步研究 在其他炎症性神经精神疾病中的行为改善提供了物质基础。
