Golbe L I
Neurology. 1987 Jul;37(7):1245-9. doi: 10.1212/wnl.37.7.1245.
In an effort to study the interaction of pregnancy and Parkinson's disease (PD), I interviewed 18 women who had had a total of 24 pregnancies after onset of PD symptoms. Conception occurred at mean age 34.7 (SD 6.1) years. There were 3 miscarriages, 4 elective abortions, and 17 term pregnancies. Use of amantadine during the first trimester was associated with a heterogeneous group of obstetric complications including miscarriage. Ten of the 17 completed pregnancies were associated with permanent worsening of PD symptoms, which did not affect overall disability. Among the series as a whole there was no excess incidence of obstetric complications or fetal defects.
为了研究妊娠与帕金森病（PD）之间的相互作用，我采访了18名女性，她们在出现PD症状后共怀孕24次。受孕时的平均年龄为34.7岁（标准差6.1岁）。有3次自然流产、4次人工流产和17次足月妊娠。孕早期使用金刚烷胺与包括流产在内的一系列不同的产科并发症有关。17次足月妊娠中有10次与PD症状的永久性加重有关，但这并未影响整体残疾状况。在整个系列中，产科并发症或胎儿缺陷的发生率并无增加。
