Luo Jingting, Zhang Chengkai, Yang Yuhang, Xiu Jingying, Zhao Hanqing, Liang Chuqiao, Feng Zhaoxun, Chen Yuning, Liu Yueming, Li Yang, Wei Wenbin
Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China.
Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Cancers (Basel). 2022 Aug 17;14(16):3960. doi: 10.3390/cancers14163960.
Uveal melanoma (UM) is the most common intraocular malignant carcinoma. This study aimed to compare the clinical features, treatment modalities, and prognosis of UM patients in China with those in America over a 15-year period. In the study, 4088 American patients with primary UM from the Surveillance, Epidemiology, and End Results (SEER) database and 1508 Chinese patients from Tongren-ophthalmology Research Association of Clinical Evaluation (TRACE) were included. Univariable and multivariable analyses were performed to determine prognostic factors and propensity score matching (PSM) and sensitivity analyses were applied to adjust for confounders and identify independent prognostic factors. Chinese patients were diagnosed at a younger age (mean ± SD, 47.3 ± 12.5 years vs. 59.7 ± 14.8 years) and tumors at diagnosis were larger (diameter: 12.0 ± 3.54 mm vs. 11.3 ± 8.27 mm; thickness: 7.13 ± 3.28 mm vs. 4.91 ± 3.01 mm). Chinese patients were more likely to undergo brachytherapy than American patients. Chinese patients had better overall survival than American patients while no significant differences exhibited after adjusting for age through PSM. In conclusion, compared with American patients, Chinese patients had younger onset age, larger tumors at diagnosis and better prognosis, mainly because of their younger age.
葡萄膜黑色素瘤（UM）是最常见的眼内恶性肿瘤。本研究旨在比较15年间中国和美国UM患者的临床特征、治疗方式及预后。该研究纳入了来自监测、流行病学和最终结果（SEER）数据库的4088例美国原发性UM患者以及来自同仁眼科临床评估研究协会（TRACE）的1508例中国患者。进行单变量和多变量分析以确定预后因素，并应用倾向评分匹配（PSM）和敏感性分析来调整混杂因素并识别独立预后因素。中国患者诊断时年龄较轻（平均±标准差，47.3±12.5岁 vs. 59.7±14.8岁），且诊断时肿瘤更大（直径：12.0±3.54 mm vs. 11.3±8.27 mm；厚度：7.13±3.28 mm vs. 4.91±3.01 mm）。与美国患者相比，中国患者更有可能接受近距离放疗。中国患者的总生存率高于美国患者，而通过PSM调整年龄后未显示出显著差异。总之，与美国患者相比，中国患者发病年龄较轻，诊断时肿瘤较大且预后较好，主要是因为他们年龄较小。
