Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, China.
Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, China.
Int J Environ Res Public Health. 2022 Aug 15;19(16):10046. doi: 10.3390/ijerph191610046.
Evidence on the association between systolic blood pressure (SBP) trajectories and arterial stiffness progression is scarce. The current study aimed to identify the association between SBP trajectories and the progression of arterial stiffness over time in Chinese adults. This study included 30,384 adult participants. Latent mixture modeling was used to identify the SBP trajectory patterns from 2006 to 2010. The brachial−ankle pulse wave velocity (baPWV) was used to measure arterial stiffness. The associations between SBP trajectories and the progression of arterial stiffness were explored using multiple linear regression models. We identified five distinct SBP trajectories and took the low-stable group as the reference. In the cross-sectional analysis, the four SBP trajectories were significantly associated with higher baPWV levels (p < 0.001) compared with the reference. In the longitudinal analysis, after adjusting for covariates and the baseline baPWV, the SBP trajectories were significantly associated with the progression of the baPWV, with corresponding β (95% CI) values of 23.3 (17.2−29.5) cm/s per year for the moderate-stable group, 44.8 (36.6−52.9) cm/s per year for the moderate-increasing group, 54.6 (42.2−67.0) cm/s per year for the elevated-decreasing group, and 66.8 (54.7−79.0) cm/s per year for the elevated-stable group. Similar significant results were also observed in the non-hypertensive population. In conclusion, SBP trajectories were related to the baseline baPWV and the progression of the baPWV. Blood pressure control may be considered a therapeutic target to further reduce the risk of arterial stiffness.
关于收缩压（SBP）轨迹与动脉僵硬度进展之间的关联的证据很少。本研究旨在确定中国成年人中 SBP 轨迹与动脉僵硬度随时间进展之间的关系。这项研究包括 30384 名成年参与者。使用潜在混合模型来识别 2006 年至 2010 年期间的 SBP 轨迹模式。使用肱踝脉搏波速度（baPWV）来测量动脉僵硬度。使用多线性回归模型探讨 SBP 轨迹与动脉僵硬度进展之间的关系。我们确定了五个不同的 SBP 轨迹，并以低稳定组作为参考。在横断面分析中，与参考组相比，四个 SBP 轨迹与更高的 baPWV 水平显著相关（p < 0.001）。在纵向分析中，调整协变量和基线 baPWV 后，SBP 轨迹与 baPWV 的进展显著相关，中度稳定组的对应β（95%CI）值为 23.3（17.2-29.5）cm/s/年，中度递增组为 44.8（36.6-52.9）cm/s/年，升高递减组为 54.6（42.2-67.0）cm/s/年，升高稳定组为 66.8（54.7-79.0）cm/s/年。在非高血压人群中也观察到类似的显著结果。总之，SBP 轨迹与基线 baPWV 和 baPWV 的进展有关。控制血压可能被认为是降低动脉僵硬度风险的治疗目标。
