中国人群中高甘油三酯性腰围表型与糖尿病血管并发症的关联
Association of Hyper-Triglyceridemic Waist Phenotype and Diabetic Vascular Complication in the Chinese Population.
作者信息
Li Kun, Cao Bin, Ke Jing, Yang Longyan, Zhao Dong
机构信息
Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, People's Republic of China.
Beijing Key Laboratory of Diabetes Research and Care, Beijing, 101149, People's Republic of China.
出版信息
Diabetes Metab Syndr Obes. 2023 Jul 26;16:2233-2241. doi: 10.2147/DMSO.S416668. eCollection 2023.
BACKGROUND
Diabetic vascular complications are the leading cause of crippling and death of diabetic patients and seriously affect patients' quality of life. It is essential to control the risk factors contributing to vascular complications in patients with Type 2 diabetes (T2DM). This study aimed to examine the association between hyper-triglyceridemic waist phenotype (HWP) and the risk of vascular complication index of diabetes in T2DM patients.
METHODS
The participants with type 2 diabetes mellitus in this study registered at the National Metabolic Management Center (MMC) of Beijing Luhe Hospital from June 2017 to June 2021. Data were collected by trained personnel according to the protocol. The questionnaire containing information on demographic characteristics and lifestyle factors (including alcohol drinking and cigarette smoking et al) was administered by trained interviewers. Logistic regression analysis assessing the associations between the hyper-triglyceridemic waist phenotype and vascular complication index of diabetes. In addition, the subgroup analysis was performed by age, sex, HbA1c, hypertension or not, and education level.
RESULTS
After data cleaning, a total of 3221 participants with T2DM were enrolled. The median (IQR) duration of diabetes was 47.00 (3.00, 125.00) months. Compared to the participants in the Normal triglycerides level and Normal waist circumference group (NTNW), those in the Elevated triglycerides level and Enlarged waist circumference group (HTGW) have a higher risk of CKD-related vascular complications; the OR of decreased estimated glomerular filtration rate (GFR) and elevated urinary albumin creatinine ratio (UACR) were 2.21 (95% CI:1.32-3.82) and 2.18 (95% CI:1.69-2.81), respectively. Moreover, compared to the participants in the NTNW group, the ORs of the decreased ankle-brachial index (ABI) and elevated Brachial-ankle pulse wave velocity (baPWV) were 2.24 (95% CI:1.38-3.80) and 1.63 (95% CI:1.28-2.06) in the HTGW group.
CONCLUSION
In summary, there was an association between hyper-triglyceridemic waist phenotype and diabetic vascular complications in the Chinese population.
背景
糖尿病血管并发症是糖尿病患者致残和死亡的主要原因，严重影响患者的生活质量。控制2型糖尿病（T2DM）患者血管并发症的危险因素至关重要。本研究旨在探讨高甘油三酯腰围表型（HWP）与T2DM患者糖尿病血管并发症指数风险之间的关联。
方法
本研究中2型糖尿病患者于2017年6月至2021年6月在北京潞河医院国家代谢管理中心（MMC）登记。由经过培训的人员按照方案收集数据。包含人口统计学特征和生活方式因素（包括饮酒和吸烟等）信息的问卷由经过培训的访谈员进行发放。采用逻辑回归分析评估高甘油三酯腰围表型与糖尿病血管并发症指数之间 的关联。此外，按年龄、性别、糖化血红蛋白、是否患有高血压以及教育程度进行亚组分析。
结果
数据清理后，共纳入3221例T2DM患者。糖尿病病程的中位数（IQR）为47.00（3.00，125.00）个月。与正常甘油三酯水平和正常腰围组（NTNW）的参与者相比，高甘油三酯水平和腰围增大组（HTGW）的参与者发生慢性肾脏病相关血管并发症的风险更高；估计肾小球滤过率（GFR）降低和尿白蛋白肌酐比值（UACR）升高的OR分别为2.21（95%CI：1.32-3.82）和2.18（95%CI：1.69-2.81）。此外，与NTNW组的参与者相比，HTGW组踝臂指数（ABI）降低和臂踝脉搏波速度（baPWV）升高的OR分别为2.24（95%CI：1.38-3.80）和1.63（95%CI：1.28-2.06）。
结论
总之，在中国人群中，高甘油三酯腰围表型与糖尿病血管并发症之间存在关联。
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