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重度创伤性脑损伤的二线和三线治疗方法。

Second- and Third-Tier Therapies for Severe Traumatic Brain Injury.

作者信息

Vrettou Charikleia S, Mentzelopoulos Spyros D

机构信息

First Department of Intensive Care Medicine, Evaggelismos General Hospital, National and Kapodistrian University of Athens Medical School, 10676 Athens, Greece.

出版信息

J Clin Med. 2022 Aug 16;11(16):4790. doi: 10.3390/jcm11164790.

DOI:10.3390/jcm11164790
PMID:36013029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9410180/
Abstract

Intracranial hypertension is a common finding in patients with severe traumatic brain injury. These patients need treatment in the intensive care unit, where intracranial pressure monitoring and, whenever possible, multimodal neuromonitoring can be applied. A three-tier approach is suggested in current recommendations, in which higher-tier therapies have more significant side effects. In this review, we explain the rationale for this approach, and analyze the benefits and risks of each therapeutic modality. Finally, we discuss, based on the most recent recommendations, how this approach can be adapted in low- and middle-income countries, where available resources are limited.

摘要

颅内高压是重型颅脑损伤患者的常见表现。这些患者需要在重症监护病房接受治疗,在该病房可进行颅内压监测,并且只要有可能,还可应用多模态神经监测。当前的推荐方案建议采用三级治疗方法,其中更高层级的治疗具有更显著的副作用。在本综述中,我们解释了这种治疗方法的基本原理,并分析了每种治疗方式的益处和风险。最后,我们根据最新的推荐方案,讨论在资源有限的低收入和中等收入国家如何调整这种治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/9410180/f87557180ab5/jcm-11-04790-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/9410180/387bf98c4564/jcm-11-04790-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/9410180/02c064d3d449/jcm-11-04790-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/9410180/f87557180ab5/jcm-11-04790-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/9410180/387bf98c4564/jcm-11-04790-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/9410180/02c064d3d449/jcm-11-04790-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3f/9410180/f87557180ab5/jcm-11-04790-g003.jpg

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Management of moderate to severe traumatic brain injury: an update for the intensivist.中重度创伤性脑损伤的治疗:重症监护医生的最新进展。
Intensive Care Med. 2022 Jun;48(6):649-666. doi: 10.1007/s00134-022-06702-4. Epub 2022 May 20.
2
Early use of barbiturates is associated with increased mortality in traumatic brain injury patients from a propensity score-based analysis of a prospective cohort.基于一项前瞻性队列的倾向评分分析,早期使用巴比妥类药物与创伤性脑损伤患者死亡率增加有关。
PLoS One. 2022 May 4;17(5):e0268013. doi: 10.1371/journal.pone.0268013. eCollection 2022.
3
Casemix, management, and mortality of patients rreseceiving emergency neurosurgery for traumatic brain injury in the Global Neurotrauma Outcomes Study: a prospective observational cohort study.
Targeted temperature control following traumatic brain injury: ESICM/NACCS best practice consensus recommendations.
颅脑损伤后目标温度管理:ESICM/NACCS 最佳实践共识推荐。
Crit Care. 2024 May 20;28(1):170. doi: 10.1186/s13054-024-04951-x.
全球神经创伤结局研究中创伤性脑损伤患者接受急诊神经外科手术的病例组合、管理和死亡率:一项前瞻性观察性队列研究。
Lancet Neurol. 2022 May;21(5):438-449. doi: 10.1016/S1474-4422(22)00037-0. Epub 2022 Mar 16.
4
"Tier-three" therapies in intracranial hypertension: is it worthwhile?颅内高压的“三线”治疗:是否值得?
Minerva Anestesiol. 2021 Dec;87(12):1287-1289. doi: 10.23736/S0375-9393.21.16117-6.
5
Moderate hypocapnia for intracranial pressure control after traumatic brain injury: a common practice requiring further investigations.创伤性脑损伤后采用中度低碳酸血症控制颅内压:一种需要进一步研究的常见做法。
Intensive Care Med. 2021 Sep;47(9):1009-1010. doi: 10.1007/s00134-021-06489-w. Epub 2021 Aug 14.
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Front Neurol. 2021 Mar 11;12:573237. doi: 10.3389/fneur.2021.573237. eCollection 2021.