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从减压性颅骨切除术到早期微创外科手术方法治疗难治性颅内压升高的演变:是优势还是社会问题?

Evolution from Decompressive Craniectomy to Early Minimally Invasive Surgical Approach for Refractory Increased Intracranial Pressure Treatment: Merit or Social Problems?

作者信息

Domi Rudin, Coniglione Filadelfo, Huti Gentian, Dauri Mario, Abdyli Asead, Lilaj Krenar, Bilotta Federico

机构信息

University of Medicine, Tirana (UMT), Department Anaesthesiology and Intensive Care, Tirana, Albania.

University of Rome Tor Vergata, Department of Anaesthesia and Intensive Care Medicine, Rome, Italy.

出版信息

Turk J Anaesthesiol Reanim. 2025 Jul 24;53(4):142-146. doi: 10.4274/TJAR.2024.241696.

Abstract

In conclusion, treating increased intracranial pressure is a significant challenge for physicians in intensive care units and emergency departments. If not managed properly, elevated intracranial pressure can lead to brain edema, reduced oxygenation, and, ultimately, death. Intracranial hypertension can be caused by various conditions, including traumatic brain injury, massive intracranial bleeding, and large ischemic stroke, such as middle cerebral artery thrombosis. Treatment consists of both pharmacological and surgical. Surgical treatments include early surgical evacuation and decompressive craniectomy (DC). DC is a critical intervention for managing refractory intracranial hypertension when all conventional therapies fail. It is a decisive step that is intended to save lives and minimize long-term neurological deficits. The procedure must be carefully planned and executed based on the patient's specific clinical scenario and needs. The decision to proceed with DC should be based on a comprehensive assessment of the patient's condition, the effectiveness of other treatments, and the potential benefits and risks of the procedure. If all conventional pharmacological and non-pharmacological therapies fail and intracranial hypertension persists, regardless of the underlying cause, DC is indicated and can be considered a critical intervention. Currently, surgical treatment has gained popularity, and many papers have been published. This review summarizes the tendencies in the literature.

摘要

总之,对于重症监护病房和急诊科的医生来说,治疗颅内压升高是一项重大挑战。如果处理不当,颅内压升高会导致脑水肿、氧合减少,并最终导致死亡。颅内高压可由多种情况引起,包括创伤性脑损伤、大量颅内出血以及大面积缺血性中风,如大脑中动脉血栓形成。治疗包括药物治疗和手术治疗。手术治疗包括早期手术清除血肿和减压性颅骨切除术(DC)。当所有传统治疗方法均失败时,DC是治疗难治性颅内高压的关键干预措施。这是一个旨在挽救生命并使长期神经功能缺损最小化的决定性步骤。该手术必须根据患者的具体临床情况和需求进行精心规划和实施。决定是否进行DC应基于对患者病情的全面评估、其他治疗方法的有效性以及该手术的潜在益处和风险。如果所有传统的药物和非药物治疗均失败且颅内高压持续存在,无论其潜在病因如何,均应进行DC,且可将其视为一项关键干预措施。目前,手术治疗越来越受欢迎,并且已经发表了许多相关论文。本综述总结了文献中的相关趋势。

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本文引用的文献

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Decompressive craniectomy for traumatic brain injury: a review of recent landmark trials.创伤性脑损伤的减压性颅骨切除术:近期标志性试验综述
Trauma Surg Acute Care Open. 2025 Apr 14;10(Suppl 1):e001784. doi: 10.1136/tsaco-2025-001784. eCollection 2025.
2
6
Intracranial pressure: current perspectives on physiology and monitoring.颅内压:生理和监测的当前观点。
Intensive Care Med. 2022 Oct;48(10):1471-1481. doi: 10.1007/s00134-022-06786-y. Epub 2022 Jul 11.

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