Murty V V, Mitra A B, Singh I P, Luthra U K
Oncology. 1987;44(3):164-8. doi: 10.1159/000226470.
C-band heteromorphisms of chromosomes 1, 9 and 16 were studied in 62 patients with cervical cancer, 100 women with various grades of precancerous lesions and 47 normal women as controls. The data showed an increased frequency of heteromorphisms of chromosome 1 in patients with cancer (48.39%) and severe dysplasias (40%) as compared to controls (29.8%) and lower grades of dysplastic lesions, i.e. mild and moderate (28.8%). The increase in the incidence of chromosome 1 heteromorphisms in cancer was found to be statistically significant (p less than 0.05) compared to controls. The present study indicates that C-band heteromorphisms may play some role in the development of malignancy of the uterine cervix.
对62例宫颈癌患者、100例不同级别癌前病变的女性以及47例正常女性作为对照，研究了1号、9号和16号染色体的C带异态性。数据显示，与对照组（29.8%）以及低级别发育异常病变（即轻度和中度，28.8%）相比，癌症患者（48.39%）和重度发育异常患者（40%）中1号染色体异态性的频率增加。与对照组相比，癌症中1号染色体异态性发生率的增加具有统计学意义（p小于0.05）。本研究表明，C带异态性可能在子宫颈恶性肿瘤的发生中起一定作用。
