Atkin N B, Brito-Babapulle V
Aust N Z J Obstet Gynaecol. 1983 May;23(2):73-6. doi: 10.1111/j.1479-828x.1983.tb00167.x.
A significantly higher incidence of heteromorphism for the size of the C-band regions of the chromosome 1 homologues was found in the lymphocytes of patients with carcinoma in situ and invasive carcinoma of the cervix uteri than in controls (15 out of 19 and 12 out of 18 patients, respectively, as compared with 13 out of 38 controls). There was also a higher incidence of partial inversions of this region in patients with carcinoma in situ and invasive carcinoma although the differences from that found in the controls were not statistically significant. C-band variants of chromosome 1 may play a part in the cytogenetic events that determine the early stages of some forms of malignancy.
与对照组相比，原位癌和子宫颈浸润癌患者淋巴细胞中1号染色体同源物C带区大小的异形性发生率显著更高（原位癌患者19例中有15例，浸润癌患者18例中有12例，而对照组38例中有13例）。原位癌和浸润癌患者中该区域部分倒位的发生率也更高，尽管与对照组相比差异无统计学意义。1号染色体的C带变异可能在决定某些恶性肿瘤早期阶段的细胞遗传学事件中起作用。
