Chromosome 1 C-band heteromorphisms in patients with carcinoma in situ and invasive carcinoma of the cervix uteri.

A significantly higher incidence of heteromorphism for the size of the C-band regions of the chromosome 1 homologues was found in the lymphocytes of patients with carcinoma in situ and invasive carcinoma of the cervix uteri than in controls (15 out of 19 and 12 out of 18 patients, respectively, as compared with 13 out of 38 controls). There was also a higher incidence of partial inversions of this region in patients with carcinoma in situ and invasive carcinoma although the differences from that found in the controls were not statistically significant. C-band variants of chromosome 1 may play a part in the cytogenetic events that determine the early stages of some forms of malignancy.