Boice Emily N, Berard David, Hernandez Torres Sofia I, Avital Guy, Snider Eric J
U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA.
Trauma & Combat Medicine Branch, Surgeon General's Headquarters, Israel Defense Forces, Ramat-Gan 52620, Israel.
J Pers Med. 2022 Aug 5;12(8):1287. doi: 10.3390/jpm12081287.
Access to the central vasculature is critical for hemodynamic monitoring and for delivery of life-saving therapeutics during emergency medicine and battlefield trauma situations but requires skill often unavailable in austere environments. Automated central vascular access devices (ACVADs) using ultrasound and robotics are being developed. Here, we present an ex vivo lower-body porcine model as a testing platform for evaluation of vascular devices and compare its features to commercially available platforms. While the commercially available trainers were simpler to set-up and use, the scope of their utility was limited as they were unable to provide realistic anatomic, physiologic, and sonographic properties that were provided by the ex vivo model. However, the ex vivo model was more cumbersome to set-up and use. Overall, both have a place in the development and evaluation pipeline for ACVADs before testing on live animals, thus accelerating product development and translation.
在急诊医学和战场创伤情况下，进入中心血管系统对于血流动力学监测和提供挽救生命的治疗方法至关重要，但这需要在艰苦环境中通常无法获得的技能。正在开发使用超声和机器人技术的自动中心血管通路装置（ACVAD）。在此，我们展示一种离体猪下半身模型作为评估血管装置的测试平台，并将其特征与市售平台进行比较。虽然市售训练器设置和使用更简单，但其效用范围有限，因为它们无法提供离体模型所具备的逼真的解剖学、生理学和超声特性。然而，离体模型设置和使用起来更加繁琐。总体而言，在对活体动物进行测试之前，两者在ACVAD的开发和评估流程中都占有一席之地，从而加速产品开发和转化。
