Emergency Institute for Cardiovascular Diseases and Transplantation Targu Mures, 540136 Mures, Romania.
Department of Surgery, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Mures, Romania.
Medicina (Kaunas). 2022 Jul 28;58(8):1009. doi: 10.3390/medicina58081009.
Cardiac undifferentiated pleomorphic sarcoma (UPS) associated with fever and inflammatory response is an extremely rare condition. Herein, we report a rare case of cardiac UPS with unusual clinical presentation and inflammatory response. A 67-year-old male complaining of progressive dyspnea and intermittent fever of unknown cause was referred to our hospital for surgical resection of a left atrial mass. Laboratory analysis showed leukocytosis (26 × 10/μL) and high C-reactive protein (CRP) levels (155.4 mg/L). Hemoculture tests and urine analysis were negative for infection. A contrast chest computed tomography revealed a mass measuring 5.5 × 4.5 cm, occupying the left atrium cavity. The patient underwent surgical excision of the mass, however, surgical margin of the resected tumor could not be evaluated, due to the multifragmented nature of the resection specimen. Postoperative CRP and leukocyte levels normalized, highlighting the relationship between the tumor and the inflammatory status. Early diagnosis is crucial for a proper management and favorable outcome, enabling patients to undergo chemotherapy and achieve complete surgical resection.
心脏未分化多形性肉瘤（UPS）伴发热和炎症反应极为罕见。本文报告了一例罕见的心脏 UPS 病例，其临床表现和炎症反应不典型。一名 67 岁男性因进行性呼吸困难和原因不明的间歇性发热就诊，我院拟行左房肿块切除术。实验室分析显示白细胞增多（26×10/μL）和 C 反应蛋白（CRP）水平升高（155.4 mg/L）。血培养和尿液分析均无感染证据。对比胸部 CT 显示一个 5.5×4.5cm 的肿块，占据左心房腔。患者接受了肿块切除术，但由于切除标本呈多碎片状，无法评估切除肿瘤的切缘。术后 CRP 和白细胞水平恢复正常，提示肿瘤与炎症状态之间存在关联。早期诊断对于适当的治疗和良好的预后至关重要，使患者能够接受化疗并实现完全手术切除。
