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口腔感染的非典型表现作为COVID-19患者侵袭性肺曲霉病的预测指标:病例报告及文献综述

Atypical Presentation of Infection in the Oral Cavity as a Prediction of Invasive Pulmonary Aspergillosis in a Patient with COVID-19: Case Report and Literature Review.

作者信息

Fiema Mateusz, Wlodarczyk Aleksandra, Wojkowska-Mach Jadwiga, Garlicki Jaroslaw, Gregorczyk-Maga Iwona

机构信息

University Hospital in Krakow, 30-688 Krakow, Poland.

Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland.

出版信息

Microorganisms. 2022 Aug 12;10(8):1630. doi: 10.3390/microorganisms10081630.

Abstract

Coinfections between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory pathogens such as have become challenging, as well as being associated with high morbidity and mortality in patients with COVID-19. is a common environmental mold. Before the emergence of COVID-19, it was considered a very rare cause of invasive pulmonary aspergillosis (IPA), occurring mainly in immunocompromised patients. The aim of this study was to describe a very rare case of IPA caused by found in the oral cavity of a mechanically ventilated COVID-19 patient. detected in the gingival pocket was diagnosed earlier than in the bronchial lavage, and without treatment, passed into the lungs of the patient, causing serious complications. The swab from the oral cavity of mechanically ventilated COVID-19 patients can be a predictor of the subsequent severity of inflammatory lesions and the development of suspected IPA.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)与其他呼吸道病原体(如……)之间的合并感染已成为一项挑战,并且与新冠肺炎患者的高发病率和死亡率相关。……是一种常见的环境霉菌。在新冠肺炎出现之前,它被认为是侵袭性肺曲霉病(IPA)的一种非常罕见的病因,主要发生在免疫功能低下的患者中。本研究的目的是描述一例在机械通气的新冠肺炎患者口腔中发现的由……引起的非常罕见的IPA病例。在牙龈袋中检测到……比在支气管灌洗中更早被诊断出来,并且未经治疗便进入患者肺部,导致严重并发症。机械通气的新冠肺炎患者口腔拭子可以作为后续炎症病变严重程度和疑似IPA发展的预测指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56a4/9413179/c877a9ba2d0a/microorganisms-10-01630-g001.jpg

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