Buleandră Mihaela, Pătrașcu Anca Aurelia, Popa Dana Elena, David Iulia Gabriela, Badea Irinel Adriana, Ciucu Anton Alexandru
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania.
Micromachines (Basel). 2022 Jul 29;13(8):1213. doi: 10.3390/mi13081213.
Guaifenesin (GFS), phenylephrine (PHE) and paracetamol (PAR), drugs used in combination for the relief of cold and flu symptoms, were determined at electrochemically pretreated pencil graphite electrode. Differential pulse voltammetry (DPV) was used for the first time for the concomitant determination of the target compounds based on the electro-oxidation of PAR at 0.43 V, PHE at 0.74 V and GFS at 1.14 V in Britton-Robinson buffer pH 6.0. Under optimized experimental conditions, two linear ranges were obtained for PAR (2.50 × 10 M-1.00 × 10 M and 1.00 × 10 M-1.00 × 10 M) and for PHE and GFS linearity was proved between 5.00 × 10 M-2.00 × 10 M and 2.50 × 10 M-2.00 × 10 M, respectively. The detection limits were 8.12 × 10 M for PAR, 1.80 × 10 M for PHE and 8.29 × 10 M for GFS. The selective and sensitive DPV method and the electrochemically treated electrode were employed for simultaneous analysis of the analytes in pharmaceutical samples with good recoveries.
愈创甘油醚（GFS）、去氧肾上腺素（PHE）和对乙酰氨基酚（PAR）是用于缓解感冒和流感症状的联合用药，在经过电化学预处理的铅笔石墨电极上对其进行了测定。差分脉冲伏安法（DPV）首次用于同时测定目标化合物，该方法基于在pH 6.0的 Britton-Robinson缓冲溶液中，PAR在0.43 V、PHE在0.74 V以及GFS在1.14 V处的电氧化反应。在优化的实验条件下，PAR获得了两个线性范围（2.50×10⁻⁶ M - 1.00×10⁻⁵ M和1.00×10⁻⁵ M - 1.00×10⁻⁴ M），PHE和GFS的线性范围分别为5.00×10⁻⁶ M - 2.00×10⁻⁵ M和2.50×10⁻⁶ M - 2.00×10⁻⁵ M。PAR的检测限为8.12×10⁻⁷ M，PHE为1.80×10⁻⁷ M，GFS为8.29×10⁻⁷ M。采用选择性和灵敏的DPV方法以及经过电化学处理的电极对药物样品中的分析物进行同时分析，回收率良好。
