Zhou Q, Zhai H Y, Pan Y F
Department of Pharmacy, GuangDong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
Department of Chemistry, GuangDong Pharmaceutical University, ZhongShan 528458, People's Republic of China.
R Soc Open Sci. 2018 Dec 5;5(12):181264. doi: 10.1098/rsos.181264. eCollection 2018 Dec.
A chemically modified carbon paste electrode (CPE) was designed by mixing graphite and multi-walled carbon nanotubes (MWCNT). The electrochemical behaviour was studied, and the determination method of phenylephrine hydrochloride (PHE) on this sensor was established. According to the results, the optimal ratio of MWCNTs was approximately 12.5% (w/w). MWCNT-modified carbon paste electrodes (MWCNT-CPEs) showed high electrochemical activity for PHE, producing a sharp oxidation peak current ( ) at approximately +0.816 V versus a saturated calomel electrode (SCE) reference electrode in phosphate buffer solution (PBS, pH 6.45), and the increased by approximately two times compared to that of the bare CPE. The anodic was linearly related with 5.0 × 10-7.5 × 10 mol l PHE, with a detection limit of 3.7 × 10 mol l. Furthermore, MWCNT-CPEs were successfully applied to the determination of PHE in injection, eye drop and nasal spray liquid samples as a simple, rapid and low-cost method.
通过将石墨与多壁碳纳米管（MWCNT）混合设计了一种化学修饰碳糊电极（CPE）。研究了其电化学行为，并建立了该传感器上盐酸去氧肾上腺素（PHE）的测定方法。结果表明，MWCNT的最佳比例约为12.5%（w/w）。MWCNT修饰的碳糊电极（MWCNT-CPE）对PHE表现出高电化学活性，在磷酸盐缓冲溶液（PBS，pH 6.45）中相对于饱和甘汞电极（SCE）参比电极在约+0.816 V处产生尖锐的氧化峰电流（），并且与裸CPE相比增加了约两倍。阳极与5.0×10 - 7.5×10 mol/L的PHE呈线性关系，检测限为3.7×10 mol/L。此外，MWCNT-CPE作为一种简单、快速且低成本的方法成功应用于注射液、滴眼液和鼻喷雾剂液体样品中PHE的测定。
