College of Pharmacy and Innovative Drug Center, Duksung Women's University, 33, Samyangro 144-gil, Dobong-gu, Seoul 01369, Korea.
Molecules. 2022 Aug 16;27(16):5224. doi: 10.3390/molecules27165224.
The studies on the selective synthesis of dialkyl selenide compounds were presented. Overcoming the complexity and difficulty of selenides (R-Se-R) and/or multiselenides (R-Se-R; ≥ 2), we aimed to optimize the reaction condition for the tolerable preparation of sodium selenide (NaSe) by reducing Se with NaBH, and then to achieve selective syntheses of dialkyl selenides by subsequently treating the obtained sodium selenide with alkyl halides (RX). Consequently, various dialkyl selenides were efficiently synthesized in good-to-moderate yields. The investigations on reaction pathways and solvent studies were also described.
本文介绍了二烷基硒化物化合物的选择性合成研究。为克服硒化物（R-Se-R）和/或多硒化物（R-Se-R；≥2）的复杂性和难度，我们旨在优化反应条件，以通过用 NaBH 还原 Se 来制备可耐受的硒化钠（NaSe），然后通过用卤代烃（RX）处理所得到的硒化钠来实现二烷基硒化物的选择性合成。因此，各种二烷基硒化物以良好至中等的收率得到高效合成。还描述了反应途径和溶剂研究的调查。
