CONACYT - Centro de Investigación en Alimentación y Desarrollo A.C., Carretera a ElDorado Km. 5.5, Col. Campo El Diez, Culiacán, Sinaloa 80110, Mexico.
Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnología-FEMSA, Av. Eugenio Garza Sada 2501 Sur, CP 64849 Monterrey, N.L., Mexico.
Food Res Int. 2019 Feb;116:676-686. doi: 10.1016/j.foodres.2018.08.096. Epub 2018 Aug 31.
Different oregano species have been traditionally used as infusions in folk medicine. Oregano medicinal properties, such as antioxidant and anti-inflammatory, have been partially attributed to its polyphenolic content. However, information regarding bioaccessibility of oregano polyphenols is limited. Cell-based antioxidant activity, and in vitro hypoglycemic, and hypolipidemic properties of polyphenolic extracts from three species of oregano species, namely, Hedeoma patens (HP), Lippia graveolens (LG) and Lippia palmeri (LP), subjected to simulated gastrointestinal digestion were evaluated. LC-TOF-MS analysis of HP, LG and LP allowed the identification of 9 flavonoids and 6 hydroxycinnamic acid derivatives with nutraceutical significance. Oregano polyphenolic extracts and digests from HP, LG, and LP exhibited cellular antioxidant capacity, hypoglycemic and hypolipidemic properties. Altogether, our results suggest that HP, LG and LP polyphenols exhibit potential for use as hypoglycemic, hypolipidemic, and antioxidant agents.
不同品种的牛至在传统医学中被用作药茶。牛至的药用特性，如抗氧化和抗炎作用，部分归因于其多酚含量。然而，关于牛至多酚的生物利用度的信息是有限的。本文评估了三种牛至物种（蓬蒿、绿薄荷和香蜂花）的多酚提取物在经过模拟胃肠道消化后的细胞抗氧化活性、体外降血糖和降血脂特性。利用 LC-TOF-MS 分析，鉴定出 9 种具有营养意义的类黄酮和 6 种对羟基肉桂酸衍生物。牛至多酚提取物和 HP、LG 和 LP 的消化物均表现出细胞抗氧化能力、降血糖和降血脂特性。总之，我们的研究结果表明，HP、LG 和 LP 的多酚具有作为降血糖、降血脂和抗氧化剂的潜力。
